AnzurstobartAnzurstobart
MedChemExpress (MCE)
HY-P990033
2543693-10-1
CC-95251
BMS-986351
98.0%
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Anzurstobart (CC-95251
BMS-986351) is a high-affinity, fully human monoclonal anti-SIRPα antibody that blocks the binding of CD47 to SIRPα. Anzurstobart enhances macrophage phagocytic activity against DLBCL cell lines in co-culture models when combined with the antibody Rituximab (HY-P9913). Anzurstobart has the potential for solid and hematologic malignancies research.
SIRPα CAS No. 2543693-10-1
Human
Human IgG1 kappa
Human IgG1 kappa, Isotype Control
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[1]. Henry Chan, et al. Discovery and Preclinical Characterization of CC-95251, an Anti-SIRPα Antibody That Enhances Macrophage-Mediated Phagocytosis of Non-Hodgkin Lymphoma (NHL) Cells When Combined with Rituximab. Blood (2021) 138 (Supplement 1): 2271.