Mepolizumab (anti-IL5) MedChemExpress (MCE)

Product Name	mepolizumab
Synonyms	Bosatria;Sb 240563;mepolizumab;Immunoglobulin G1, anti-(human interleukin 5) (human-mouse monoclonal sb-240563 gamma1-chain), disulfide with human-mouse monoclonal sb-240563 kappa-chain, dimer
CAS	196078-29-2
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Mepolizumab (anti-IL5) Mepolizumab (anti-IL5) MedChemExpress (MCE) HY-P9945A 196078-29-2 97.50% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma. Mepolizumab shows nearly linear PK after intravenous administration over a 6000-fold dose range (0.05-300 mg/kg), inhibiting eosinophil proliferation with an IC50 of 1.43 mg/mL[1]. Pharmacokinetic analysis of mepolizumab in cynomolgus monkeys[1] Route Dose (mg/kg) Cmax (μg/mL) AUC0-INF_obs (μg·h/mL) T1/2 (days) Clobs (mL·h/kg) Vss_obs (mL/kg) i.v. 300 6700 1405000 11.7 0.217 74.6 i.v. 3 89.1 14600 11.2 0.208 82.1 Humanized Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. P Zia-Amirhosseini, et al. Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther. 1999 Dec Descriptions Mepolizumab (anti-IL5) Mepolizumab (anti-IL5) MedChemExpress (MCE) HY-P9945A 196078-29-2 97.50% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma. Mepolizumab shows nearly linear PK after intravenous administration over a 6000-fold dose range (0.05-300 mg/kg), inhibiting eosinophil proliferation with an IC50 of 1.43 mg/mL[1]. Pharmacokinetic analysis of mepolizumab in cynomolgus monkeys[1] Route Dose (mg/kg) Cmax (μg/mL) AUC0-INF_obs (μg·h/mL) T1/2 (days) Clobs (mL·h/kg) Vss_obs (mL/kg) i.v. 300 6700 1405000 11.7 0.217 74.6 i.v. 3 89.1 14600 11.2 0.208 82.1 Humanized Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. P Zia-Amirhosseini, et al. Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther. 1999 Dec 291(3):1060-7. [Content Brief] [2]. Tim Harrison, et al. Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis. Eur Respir J. 2020 Oct 15 56(4):2000151. [Content Brief] [3]. Ian D Pavord, From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases. Allergy. 2022 Mar 77(3):778-797. [Content Brief]
Last Update	2025-04-01 14:45:47

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