Chondroitin sulfate sodium (from shark cartilage) MedChemExpress (MCE)

Product Name	Chondroitin sulfate sodium salt
Synonyms	CSA Chondron CHONDROITIN-6-SULFATE Chondroitin Sulfate Sodium Chondroitin Sulphate Sodium Chondroitinpolysulfatesodium CHONDROITIN-6-SULFATE, SHARK Synonyms CSA Chondron CHONDROITIN-6-SULFATE Chondroitin Sulfate Sodium Chondroitin Sulphate Sodium Chondroitinpolysulfatesodium CHONDROITIN-6-SULFATE, SHARK Sodiumchondroitinpolysulfate Chondroitin sulfate sodium salt Chondroitin sulfate A sodium salt Chondroitin,hydrogensulfate,sodiumsalt Chondroitin Sulphate Sodium Terrestrial Origin chondroitin4-sulfatesodiumsaltfrombovinetrachea chondroitin 4-sulfate sodium salt from bovine trachea [(2R,3R,4R,5R,6R)-5-acetamido-4-[(2S,3S,4R,5R,6R)-6-carboxy-3,4,5-trihydroxy-tetrahydropyran-2-yl]oxy-6-hydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxysulfonylperoxysodium
CAS	9082-07-9;39455-18-0
EINECS	618-658-8
Chemical Formula	C42H57N3Na6O43S3X2
Molecular Weight	1526.03
inchi	InChI=1/C14H23NO16S.Na/c1-3(17)15-5-10(9(30-32(25,26)31-24)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22 /h4-11,13-14,16,18-20,23-24H,2H2,1H3,(H,15,17)(H,21,22) /q +1/p-1/t4-,5-,6-,7-,8+,9+,10-,11-,13-,14+ inchi InChI=1/C14H23NO16S.Na/c1-3(17)15-5-10(9(30-32(25,26)31-24)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22 /h4-11,13-14,16,18-20,23-24H,2H2,1H3,(H,15,17)(H,21,22) /q +1/p-1/t4-,5-,6-,7-,8+,9+,10-,11-,13-,14+ /m1./s1/rC14H22NNaO16S/c1-3(18)15-5-10(28-14-8(21)6(19)7(20)11(29-14)12(22)23)9(4(2-17)27-13(5)24)30-33(25,26)32-31-16/h4-11,13-14,17,19-21,24H,2H2,1H3,(H,15,18)(H,22,23)/t4-,5-,6-,7-,8+,9+,10-,11-,13-,14+/m1/s1
Package	250 mg;1 g
Price	Email to quote
Descriptions	Chondroitin sulfate sodium (from shark cartilage) Chondroitin sulfate sodium (from shark cartilage) MedChemExpress (MCE) HY-B2162A 9082-07-9 Chondroitin polysulfate sodium (from shark cartilage) 99.52% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Chondroitin sulfate sodium (from shark cartilage) Chondroitin sulfate sodium (from shark cartilage) MedChemExpress (MCE) HY-B2162A 9082-07-9 Chondroitin polysulfate sodium (from shark cartilage) 99.52% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Chondroitin sulfate sodium (from shark cartilage), one of five classes of glycosaminoglycans, has been widely used in the treatment of osteoarthritis. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS and MMPs. Chondroitin sulfate sodium (from shark cartilage) is a class of sulfated glycosaminoglycans that are linear polysaccharides consisting of repeating disaccharide units composed of uronic acid and N-acetylhexosamine. Several pathogens including parasites, bacteria, and viruses have been shown to utilize cell surface chondroitin sulfate chains to attach to and infect host cells[1]. Chondroitin sulfate occurs naturally in the extracellular matrix of connective tissues, e.g., bone, cartilage, skin, ligaments and tendons. Chondroitin sulfate has been shown to elicit a range of beneficial effects: anti-inflammatory effects, an increase in type II collagen and proteoglycans, a reduction in bone resorption and a better anabolic/catabolic balance in chondrocytes[2]. A large range of chondroitin sulfate concentrations has been used (e.g. 12.5 to 2000 mg/mL, but generally less than200 mg/mL) in in vitro studies. Chondroitin sulfate (200 mg/mL) decreases the chondrocyte susceptibility to single nucleotide polymorphism-induced apoptosis[3]. Chondroitin sulfate reduces inflammation mediators and the apoptotic process and is able to reduce protein production of inflammatory cytokines, iNOS, MMPs[4]. The high content of chondroitin sulfate in the aggrecan plays a major part in allowing cartilage to resist tensile stresses during various loading conditions by providing this tissue with resistance and elasticity. It has been shown that chondroitin sulphate interferes with the progression of structural changes in joint tissues and is used in the management of patients with osteoarthritis[3]. Chondroitin sulfate is mostly administered orally at doses ranging from 800 to 1200mg/day. Chondroitin sulfate is rapidly absorbed by the gastrointestinal tract. The absorbed chondroitin sulfate reaches the blood compartment as 10% chondroitin sulfate and 90% depolymerized low-molecular-weight derivatives[5]. iNOS Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Mikami T, et al. Biosynthesis and function of chondroitin sulfate. Biochim Biophys Acta. 2013 Oct 1830(10):4719-33. [Content Brief] [2]. Monfort J, et al. Biochemical basis of the effect of chondroitin sulphate on osteoarthritis articular tissues. Ann Rheum Dis. 2008 Jun 67(6):735-40. [Content Brief] [3]. Martel-Pelletier J, et al.Discrepancies in composition and biological effects of different formulations of chondroitin sulfate. Molecules. 2015 Mar 6 20(3):4277-89. [Content Brief] [4]. Campo GM, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem. 2009 Jan 1 106(1):83-92. [Content Brief] [5]. Henrotin Y, et al. Chondroitin sulfate in the treatment of osteoarthritis: from in vitro studies to clinicalrecommendations. Ther Adv Musculoskelet Dis. 2010 Dec 2(6):335-48. [Content Brief]
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Last Update	2025-05-21 16:50:25

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