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| Supplier Name | MedChemExpress (MCE) |
| Contact | sales |
| Tel | 609-228-6898 |
| Mobile | 609-228-6898 |
| sales@medchemexpress.com; tech@medchemexpress.com | |
| Website | https://www.medchemexpress.com/ |
| Product Name | 4-Hydroxyphenylacetic acid |
| Synonyms | NSC 27460 4-carboxymethylphenol Arbidol Impurity F HCl (4-hydroxyphenyl)acetate p-Hydroxyphenylacetic acid 4-Hydroxyphenylacetic acid (p-hydroxyphenyl)-aceticaci |
| CAS | 156-38-7 |
| EINECS | 205-851-3 |
| Chemical Formula | C8H8O3 |
| Molecular Weight | 152.15 |
| inchi | InChI=1/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 |
| Package | 25 mg;50 mg;100 mg;250 mg |
| Price | Email to quote |
| Descriptions | 4-Hydroxyphenylacetic acid (Standard) 4-Hydroxyphenylacetic acid (Standard) MedChemExpress (MCE) HY-N1902R 98% Please store the product under the recommended conditions in the Certificate of Analysis. 4-Hydroxyphenylacetic acid (Standard) is the analytical standard of 4-Hydroxyphenylacetic acid. This product is intended for research and analytical applications. 4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2. IC50 & Target:Nrf2 In Vivo: 4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1. |
| Last Update | 2025-04-01 14:45:47 |
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