SBE-β-CD MedChemExpress (MCE)

Product Name	beta.-Cyclodextrin, sulfobutyl ethers, sodium salts
Synonyms	SBE7-beta-CD sulfobutyl ether sodium salt BETADEX SULFOBUTYL ETHER SOIDUM betadex sulfobuytl ether sodium β-Cyclodextrin, sulfobutyl ethers Sodium sulfobutylether β-cyclodextrin Sulfobutylated beta-cyclodextrin sodium salt (DS~4) Synonyms SBE7-beta-CD sulfobutyl ether sodium salt BETADEX SULFOBUTYL ETHER SOIDUM betadex sulfobuytl ether sodium β-Cyclodextrin, sulfobutyl ethers Sodium sulfobutylether β-cyclodextrin Sulfobutylated beta-cyclodextrin sodium salt (DS~4) Sulfobutylated beta-cyclodextrin sodium salt (DS~6) beta.-Cyclodextrin, sulfobutyl ethers, sodium salts .beta.-Cyclodextrin, sulfobutyl ethers, sodium salts SBE-β-CD(Sulfobutyl Ether-β-cyclodextrin Sodium salt)
CAS	182410-00-0;194615-04-8
EINECS	1308068-626-2
Chemical Formula	C42H70O35
Molecular Weight	1134.9842
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Package	500 mg;1 g;5 g;10 g;25 g;50 g
Price	Email to quote
Descriptions	SBE-β-CD SBE-β-CD MedChemExpress (MCE) HY-17031 182410-00-0 Sulfobutylether-β-Cyclodextrin 99.89% 4°C, sealed storage, away from moisture and light Room temperature in continental US Descriptions SBE-β-CD SBE-β-CD MedChemExpress (MCE) HY-17031 182410-00-0 Sulfobutylether-β-Cyclodextrin 99.89% 4°C, sealed storage, away from moisture and light Room temperature in continental US may vary elsewhere. SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents. SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range[1]. 20% SBE-β-CD in saline: Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs). 1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution. 2. Measure 2 g of dry SBE-β-CD. 3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use. Rats[2] A 300 g rat is administered with 1 mL of a 0.1 M SBE-β-CD solution containing 5.64 mg of Compound 1, and assuming an extracellular volume of 90 mL, less than 0.1% of the complex would rapidly dissociate due to the initial effects of dilution. This calculation, combined with the changing blood to plasma ratio in the presence of SBE-β-CD, provides a reasonable explanation for the observed differences in the blood and plasma profiles of Compound 1 after intravenous administration in either the cyclodextrin or cyclodextrin-free formulations. After IV administration of the cyclodextrin formulation, Compound 1 would initially be prevented from distributing into erythrocytes thereby resulting in a whole blood to plasma ratio of less than one. Subsequently, clearance of SBE-β-CD from the circulation would lead to changes in the complexation equilibrium such that the unbound fraction of Compound 1 would increase, thereby reestablishing normal blood to plasma partitioning (i.e. in favour of whole blood) and clearance. \| \| \| \| \| \| \| \| \| \| [1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28 350(1-2):188-196 [Content Brief] [2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb 95(2):256-67 [Content Brief]
Supplier Website	https://www.medchemexpress.com/SBE-_beta_-CD.html
Last Update	2025-05-21 16:50:25

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