Ascomycin MedChemExpress (MCE)

Product Name	Ascomycin
Synonyms	AAG FK-520 C058028 FR-900520 Ascomycin IMMUNOMYCIN AscoMycin solution Synonyms AAG FK-520 C058028 FR-900520 Ascomycin IMMUNOMYCIN AscoMycin solution Tacrolimus USP RC A Tacrolimus Imprity 6 ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS L 683590, FR 900520, IMMunoMycin, FK 520, WS 7238A, NSC 106410 12,18-tetramethyl-,(3s-(3r(e(1s,3s,4s)),4s,19s,26ar*))--10 8-ethyl-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy 15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram (3S,4R,5S,8R,12S,14R,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-{(E)-2-[(1S,3R,4S)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone (3S,4R,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone (3S,4S,5S,8R,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
CAS	104987-12-4;11011-38-4
EINECS	600-627-5
Chemical Formula	C43 H69 N O12
Molecular Weight	792.01
inchi	InChI=1/C43H67NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-32,35-39,45,51H,10-17,19,21-23H2,1-9H3/b24-18-,26-20+/t25-,27-,28-,29+,30-,31+,32-,35-,36+,37+,38-,39-,43-/m1/s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Ascomycin Ascomycin MedChemExpress (MCE) HY-13557 104987-12-4 Immunomycin Descriptions Ascomycin Ascomycin MedChemExpress (MCE) HY-13557 104987-12-4 Immunomycin FR-900520 FK520 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Ascomycin (Immunomycin FR-900520 FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research. Ascomycin (FR-900520) suppresses immune response in vitro with an IC50 value of 0.55 nM for mouse mixed lymphocyte reaction[1]. Ascomycin is a powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN and to interfere with the dephosphorylation of various substrates[3]. Ascomycin (FR-900520 i.m. 0.32-32 mg/kg 5 days a week for 2 weeks) clearly prolongs skin allograft survival in rats[1]. Plasmodium \| \| \| \| \| \| \| \| \| \| [1]. Hatanaka H, et al. FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physico-chemical and biological characteristics. J Antibiot (Tokyo). 1988 Nov 41(11):1592-601. [Content Brief] [2]. Krishika Sambyal, et al. Bioprocess and genetic engineering aspects of ascomycin production: a review. J Genet Eng Biotechnol. 2020 Nov 19 18(1):73. [Content Brief] [3]. Germán Sierra-Paredes, et al. Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. CNS Neurosci Ther. Spring 2008 14(1):36-46. [Content Brief]
Last Update	2025-04-01 14:45:47

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