Atazanavir sulfate MedChemExpress (MCE)

Product Name	Atazanavir Sulfate
Synonyms	Aids060276 Aids-060276 BMS232632 SULFATE BMS232632 sulfate BMS 232632 SULFATE Atazanavir Sulfate BMS 232632 sulfate Synonyms Aids060276 Aids-060276 BMS232632 SULFATE BMS232632 sulfate BMS 232632 SULFATE Atazanavir Sulfate BMS 232632 sulfate BMS-232632 SULFATE BMS-232632 sulfate Atazanavir Sulphate 1-(4-Biphenylyl)-4(S)-hydroxy-5(S)-2,5-bis{[N-(methoxycarbonyl-)-L-tert-leucinyl]amino}-6-phenyl-2-azahexane N-[(2S)-1-[2-[(2S,3S)-2-hydroxy-3-[[(2S)-2-(methoxycarbonylamino)-3,3-dimethyl-1-oxobutyl]amino]-4-phenylbutyl]-2-[(4-phenylphenyl)methyl]hydrazinyl]-3,3-dimethyl-1-oxobutan-2-yl]carbamic acid methyl Methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate sulfate
CAS	229975-97-7
EINECS	620-495-2
Chemical Formula	C38H52N6O7.H2SO4
Molecular Weight	802.93
inchi	InChI=1/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28 1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47) inchi InChI=1/C38H52N6O7.H2O4S/c1-37(2,3)31(41-35(48)50-7)33(46)40-29(22-25-14-10-9-11-15-25)30(45)24-44(43-34(47)32(38(4,5)6)42-36(49)51-8)23-26-17-19-27(20-18-26)28-16-12-13-21-39-28 1-5(2,3)4/h9-21,29-32,45H,22-24H2,1-8H3,(H,40,46)(H,41,48)(H,42,49)(H,43,47) (H2,1,2,3,4)/t29-,30-,31+,32+ /m0./s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Atazanavir sulfate Atazanavir sulfate MedChemExpress (MCE) HY-17367A 229975-97-7 BMS-232632 sulfate 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Atazanavir sulfate Atazanavir sulfate MedChemExpress (MCE) HY-17367A 229975-97-7 BMS-232632 sulfate 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Atazanavir (BMS-232632) sulfate is a highly selective and orally active HIV-1 protease inhibitor . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor of P-glycoprotein (P-gp). Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM. Atazanavir sulfate inhibits cardiac fibrosis, hyperlipidemia and induces malignant glioma death. Atazanavir (1-10 μM, 72 h) attenuates hypoxia induced rat cardiac fibroblasts (rCFs) s proliferation by modulating the HMGB1/TLR 9 pathway[4]. Atazanavir (1-10 μM, 72 h) inhibits collagen I, collagen III, HMGB1, p-IκBα and p-NF-κB expression levels in rat cardiac fibroblasts[4]. Atazanavir (1-10 μM, 48 h) inhibits the growth of A, U251, T98G, LN229 cells and induces ESR (endoplasmic reticulum stress response) in U251, T98G, and LN229 cells[6]. Atazanavir (6.0 μM) elicites Ca2+ transients and blebbing of the plasma membranes of C2C12 skeletal muscle myotubes[7]. Atazanavir (30 mg/kg, i.g., daily, 4 weeks) reduces collagen deposition and inhibits cardiac remodeling in myocardial infarction (MI) model rats[4]. CYP3 HIV-1 Dose Route Indicator value Rat 7mg/kg i.v. T1/2 1.13hr Rat 7mg/kg p.o. Cmax 0.54μg/mL Rat 7mg/kg i.p. T1/2 1.22hr Rat 7mg/kg i.v. AUC0-∞ 4.09μg·h/mL Rat 7mg/kg p.o. Tmax 2.25hr Rat 7mg/kg i.p. AUC0-∞ 3.38μg·h/mL Rat 7mg/kg i.v. CLtotal 1.77L/h/kg Rat 7mg/kg p.o. T1/2 1.04hr Rat 7mg/kg i.v. Vss 2.23L/kg Rat 7mg/kg p.o. AUC0-∞ 1.70μg·h/mL \| \| \| \| \| \| \| \| \| \| [1]. Havlir DV, et al. Atazanavir: new option for treatment of HIV infection. Clin Infect Dis. 2004 Jun 1 38(11):1599-604. [Content Brief] [2]. Wood R. Atazanavir: its role in HIV treatment. Expert Rev Anti Infect Ther. 2008 Dec 6(6):785-96. [Content Brief] [3]. Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29 6(1):212. [Content Brief] [4]. Zhang G, et al. Long-term oral atazanavir attenuates myocardial infarction-induced cardiac fibrosis. Eur J Pharmacol. 2018 Jun 5 828:97-102. [Content Brief] [5]. Fukushima K, et al. Effect of serum lipids on the pharmacokinetics of atazanavir in hyperlipidemic rats. Biomed Pharmacother. 2009 Nov 63(9):635-42. [Content Brief] [6]. Pyrko P, et al. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007 Nov 15 67(22):10920-8. [Content Brief] [7]. Alomar FA, et al. Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum Ca2+ homeostasis in skeletal muscles. Antiviral Res. 2021 Mar 187:104975. [Content Brief] [8]. Robillard KR, et al. Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract. Antimicrob Agents Chemother. 2014 58(3):1713-22. [Content Brief]
Last Update	2025-04-01 14:45:47

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