Mianserin hydrochloride MedChemExpress (MCE)

Product Name	mianserin hydrochloride
Synonyms	Mianserin HCl MIANSERIN HCL MIANSERINE HCL Mianserin Hydrocloride mianserin hydrochloride MIANSERIN HYDROCHLORIDE MIANSERINE HYDROCHLORIDE Synonyms Mianserin HCl MIANSERIN HCL MIANSERINE HCL Mianserin Hydrocloride mianserin hydrochloride MIANSERIN HYDROCHLORIDE MIANSERINE HYDROCHLORIDE MIANSERIN HYDROCHLORIDE SEROTONIN ANTAGO NIST 2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine 1,2,3,4,10,14b-hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepinehydrochlo 1,2,3,4,10,14B-HEXAHYDRO-2-METHYL-DIBENZO[C,F]PYRAZINO[1,2-A]AZEPINE HYDROCHLORIDE 1,2,3,4,10,14BETA-HEXAHYDRO-2-METHYL-DIBENZO-[C,F]PYRAZINO[1,2-A]AZEPINE HYDROCHLORIDE
CAS	21535-47-7
EINECS	244-426-7
Chemical Formula	C18H21ClN2
Molecular Weight	300.83
inchi	InChI=1/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
Package	10 mM * 1 mL;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Mianserin hydrochloride Mianserin hydrochloride MedChemExpress (MCE) HY-B0188A 21535-47-7 Org GB 94 99.87% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years Descriptions Mianserin hydrochloride Mianserin hydrochloride MedChemExpress (MCE) HY-B0188A 21535-47-7 Org GB 94 99.87% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years -20°C, 1 year (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant. Mianserin hydrochloride (Org GB 94) is a psychoactive drug of the tetracyclic antidepressant (TeCA) therapeutic family. It is classified as a noradrenergic and specific serotonergic antidepressant (NaSSA) and has antidepressant, anxiolytic (anti-anxiety), hypnotic (sedating), antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating), and antihistamine effects. It is not approved for use in the US, but its analogue, mirtazapine, is. Mianserin was the first antidepressant to reach the UK market that was less dangerous than the tricyclic antidepressants in overdose. Mianserin is an antagonist/inverse agonist of the H1, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT6, 5-HT7, α1-adrenergic, and α2-adrenergic receptors, and also inhibits the reuptake of norepinephrine. As a high affinity H1 receptor inverse agonist, mianserin has strong antihistamine effects (sedation, weight gain, etc.). Contrarily, it has negligible affinity for the mACh receptors, and thus lacks any anticholinergic properties. It was recently found to be a potent kappa opioid receptor agonist. In addition, mianserin also appears to be a potent antagonist of the neuronal octopamine receptor. What implications this may have on mood are currently unknown, however octopamine has been implicated in the regulation of sleep, appetite and insulin production and therefore may theoretically contribute to the overall side effect profile of mianserin. H1 Receptor \| \| \| \| \| \| \| \| \| \| [1]. Olianas MC,et al. The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors. Br J Pharmacol. 2012 Nov 167(6):1329-41. [Content Brief] [2]. Roeder T. High-affinity antagonists of the locust neuronal octopamine receptor. Eur J Pharmacol. 1990 Nov 27 191(2):221-4. [Content Brief]
Last Update	2025-04-01 14:45:47

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