Gossypol MedChemExpress (MCE)

Product Name	gossypol
Synonyms	gossypol GOSSYPOL Thespesin NSC 56817 NSC 624336 GOSSYPOL(P) TIMTEC-BB SBB012338 Synonyms gossypol GOSSYPOL Thespesin NSC 56817 NSC 624336 GOSSYPOL(P) TIMTEC-BB SBB012338 GOSSYPOL, COTTON SEEDS 2,2'-BIS[8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPTHALENE] 2,2'-BI[8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPHTHALENE] 2,2'-BIS[8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPHTHALENE] 2,2'-bis(1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthalene) Gossypol from cotton seeds,2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene) 1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-[2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE
CAS	303-45-7
EINECS	636-899-7
Chemical Formula	C30H30O8
Molecular Weight	518.55
inchi	InChI=1/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Gossypol Gossypol MedChemExpress (MCE) HY-13407 303-45-7 BL 193 99.67% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Gossypol Gossypol MedChemExpress (MCE) HY-13407 303-45-7 BL 193 99.67% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Gossypol binds to Bcl-xL protein and Bcl-2 protein with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. Gossypol, a natural product isolated from cottonseeds and roots that has been studied as an anticancer agent. The racemic form of Gossypol [(±)-Gossypol] is tested in several clinical trials and is well tolerated. The racemic form Gossypol ((±)-Gossypol) binds to Bcl-xL protein with a Ki of 0.5 to 0.6 μM. (±)-Gossypol also potently binds to Bcl-2 protein with a Ki value of 0.2-0.3 mM. The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (+)-Gossypol enantiomers. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P[1]. Two representative UM-SCC cell lines, UM-SCC-6 and UM-SCC-14A, are continuously exposed to 0 (vehicle control), 5 or 10 μM (±)-Gossypol, (-)-Gossypol or (+)-Gossypol in a 6-day MTT cell survival assay[1]. Bcl-xL 0.5-0.6 μM (Ki) Bcl-2 0.2-0.3 mM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15 10(22):7757-63. [Content Brief]
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Last Update	2025-05-21 16:50:25

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