NitrofurazoneNitrofurazone
MedChemExpress (MCE)
HY-B0226
59-87-0
Nitrofural
99.86%
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Room temperature in continental US
may vary elsewhere.
Nitrofurazone (Nitrofural) is a broad spectrum antibiotic that has oral activity. Nitrofurazone is a nitro-aromatic drug. Nitrofurazone is active against both Gram-positive and Gram-negative bacteria.
Nitrofurazone (10-20 μg/mL) can make E. coli strain B/r triple resistant mutants, increasing drug resistance by 6 to 7 times[2]. Nitrofurazone (50 μg/mL, 30 min) inhibits the synthesis of all color RNA and ribosomal subunits and the formation of polysomes in E. coli strain B/r[3].
Nitrofurazone can be used to create breast tumor models. The pharmacokinetic characteristics of Nitrofurazone in male white rabbits show a high clearance constant (0.04) and a short elimination half-life (17.32 minutes) with an AUC0-∞ of 844.79 when administered intravenously. When given orally, Nitrofurazone exhibits a lower clearance constant (0.002), a longer elimination half-life (276.09 minutes), and an AUC0-∞ of 566.44. After oral administration, the mean residence time of Nitrofurazone is 956.1 minutes, significantly longer than the 496.3 minutes observed after intravenous administration[4][5][6][7]. .f12{ font-size: 12px
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} Induction of breast tumor[5] Background Nitrofurazone, with the involvement of cytochrome P450 reductase, generates metabolites that cause oxidative damage to the DNA of MCF-7 cells (human breast cancer-derived cells). At the same time, Amiodarone itself promotes cell proliferation and increases serum prolactin and progesterone levels in rats, thereby inducing breast cancer[4][5][6]. Specific Mmodeling Methods Rat: Wistar • female • 4-week-oldAdministration: diets containing 1000 ppm of Nitrofurazone • po • once daily, between 8 and 27 weeks of age Note Two-Stage Breast Cancer Induction Method:1. At 7 weeks of age, each rat is administered a single dose of 20 mg of DMBA (9,10-dimethyl-1,2-benzanthracene) orally. DMBA is dissolved in sesame oil at a concentration of 2% before use.2. From 8 to 27 weeks of age, each rat is given a diet containing 1000 ppm of Nitrofurazone daily (ppm: parts per million, indicating the amount of Nitrofurazone per million units of the diet
for example, a concentration of 1000 ppm means 1 g of Nitrofurazone in 1 kg of feed).、 Modeling Indicators Hormonal Changes: Significant increases in serum prolactin and progesterone levels in rats.Histological Changes: Development of mammary tumors, with the vast majority being adenocarcinomas, and a very small number potentially being fibrosarcomas. Correlated Product(s): DMBA (HY-W011845) Opposite Product(s): /
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[1]. Ryan A, et al. Activation of nitrofurazone by azoreductases: multiple activities in one enzyme. Sci Rep. 2011
1:63. [Content Brief]
[2]. McCalla DR, et al. Mode of action of nitrofurazone. J Bacteriol. 1970 Dec
104(3):1126-34. [Content Brief]
[3]. Tu Y, et al. Effect of nitrofurazone on bacterial RNA and ribosome synthesis and on the function of ribosomes. Chem Biol Interact. 1976 Jul
14(1-2):81-91. [Content Brief]
[4]. Z Kari FW, et al. Toxicity and carcinogenicity of nitrofurazone in F344/N rats and B6C3F1 mice. Food Chem Toxicol. 1989 Feb
27(2):129-37. [Content Brief]
[5]. Neal RA, et al. The activity of nitrofurazone and furazolidone against Leishmania donovani, L. major and L. enriettii in vitro and in vivo. Ann Trop Med Parasitol. 1988 Oct
82(5):453-6. [Content Brief]
