Pentoxifylline MedChemExpress (MCE)

Product Name	Pentoxifylline
Synonyms	PTX;TRENTAL;Pentoxifylline;PENTOXYPHYLINE;PENTOXIFYLLINE;PENTOXYFYLLINE;PENTOXYIFYLLINE;1-(5-Oxohexyl)-3,7-dimethylxanthine;3,7-DIHYDRO-3,7-DIMETHYL-1-(5-OXOHEXYL)-1H-PURINE-2,6-DIONE
CAS	6493-05-6
EINECS	229-374-5
Chemical Formula	C13H18N4O3
Molecular Weight	278.31
inchi	InChI=1/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
Package	10 mM * 1 mL;500 mg;1 g
Price	Email to quote
Descriptions	Pentoxifylline Pentoxifylline MedChemExpress (MCE) HY-B0715 6493-05-6 BL-191 Descriptions Pentoxifylline Pentoxifylline MedChemExpress (MCE) HY-B0715 6493-05-6 BL-191 PTX Oxpentifylline 99.92% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation. Pentoxifylline (0.1-50 mM 24-48 hours) inhibits cell proliferation in a dose-dependent manner[3]. Pentoxifylline (0.5 mM 12-36 hours) increases apoptosis and decreases autophagy levels in MDA-MB-231 cells[3]. Pentoxifylline (0.5 mM 12-36 hours) induces autophagy in MDA-MB-231 cells[3]. Pentoxifylline (0.5 mM 24-48 hours) blocks cell cycle at the G0/G1 phase[3]. Pentoxifylline results in high LC3-II/LC3-ratio[3]. Pentoxifylline (200 mg/kg i.p.) has a protective effect on rats with transient global ischemia and reduces cognitive impairment[4]. PDE[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Iffat Hassan, et al. Pentoxifylline and its applications in dermatology. Indian Dermatol Online J. 2014 Oct-Dec 5(4): 510–516. [Content Brief] [2]. A Ward, et al. Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs. 1987 Jul 34(1):50-97. [Content Brief] [3]. Yessica Cristina Castellanos-Esparza, et al. Synergistic promoting effects of pentoxifylline and simvastatin on the apoptosis of triple-negative MDA-MB-231 breast cancer cells. Int J Oncol. 2018 Apr 52(4):1246-1254. [Content Brief] [4]. Shabnam Movassaghi, et al. Effect of Pentoxifylline on Ischemia- induced Brain Damage and Spatial Memory Impairment in Rat. Iran J Basic Med Sci. 2012 Sep-Oct 15(5): 1083-1090. [Content Brief]
Last Update	2025-04-01 14:45:47

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