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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product Name13,14-dimethoxy-6,7-dimethyl-5,6,7,8-tetrahydro[1,3]benzodioxolo[5',6':3,4]cycloocta[1,2-f][1,3]benzodioxole (non-preferred name)
SynonymsWUWEIZISU C;,8-dimethyl-;Schizandrin C;Schisandrin C;SCHIZANDRIN C;(S)-(-)-Schisandrin C;Schisandrin C (Schizandrin-C;Schisandrin C (S)-(-)-Schisandrin C
CAS61301-33-5
EINECS
Chemical FormulaC22H24O6
Molecular Weight384.42
inchiInChI=1/C22H24O6/c1-11-5-13-7-15-19(27-9-25-15)21(23-3)17(13)18-14(6-12(11)2)8-16-20(22(18)24-4)28-10-26-16/h7-8,11-12H,5-6,9-10H2,1-4H3
Package10 mM * 1 mL;5 mg;10 mg;50 mg
PriceEmail to quote
DescriptionsSchisandrin C

Schisandrin C

MedChemExpress (MCE)

HY-N0690

61301-33-5

Schizandrin-C

Descriptions

Schisandrin C

Schisandrin C

MedChemExpress (MCE)

HY-N0690

61301-33-5

Schizandrin-C
Wuweizisu-C

99.95%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Room temperature in continental US
may vary elsewhere.

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis. Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory?and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases?research. Schisandrin C induces cell apoptosis.

Schisandrin C (25-100 μM
48 hours) down-regulates expression levels of Bcl-2, Bcl-xL and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). It also activates caspase-3 and -9 in U937 cells[2].Schisandrin C (25-100 μM
48 hours) induces apoptosis in a dose-dependent manner. And the fragmentation of genomic DNA is also increased in U937 cells[1].Schisandrin C (25-100 μM
72 hours) induces G1 arrest, it down-regulates cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, and also exhibits inhibition of pRB, and up-regulation of the Cdk inhibitor p21(WAF1/CIP1)[1].

Schisandrin C (lateral ventricle injection (i.c.v.)
15-150 μg/kg
5 days) reduces Aβ1-42-induced memory deficits in the Y-maze test. Neurons in the hippocampus of SCH-C (15 μg/kg)-treated group returned to normal level, and and SCH-C group (150 μg/kg) has slight neuroprotective effects Aβ1-42-induced group. SCH-C (15 μg/kg) recoveres the activities of SOD and GSHPx and the ratios of GSH, decreases the levels of ChEtotal in the brain of the Aβ1–42-induced amnesic mice simultaneously[3].

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[1]. Park C, et al. Induction of G1 arrest and apoptosis by schisandrin C isolated from Schizandra chinensis Baill in human leukemia U937 cells. Int J Mol Med. 2009 Oct
24(4):495-502. [Content Brief]

[2]. Oh SY, et al. Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Biosci Biotechnol Biochem. 2010
74(2):285-91. [Content Brief]

[3]. Xin Mao, et al.Schisandrin C Ameliorates Learning and Memory Deficits by Aβ 1-42 -induced Oxidative Stress and Neurotoxicity in Mice. Phytother Res. 2015 Sep
29(9):1373-1380. [Content Brief]

[4]. Uehara T, et, al. Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Nat Chem Biol. 2017 Jun
13(6):675-680. [Content Brief]

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