Paromomycin sulfate MedChemExpress (MCE)

Product Name	Paromomycin sulfate
Synonyms	fi5853 NEOMYCIN E aminosidinsulfate aminosidinesulfate aminosidinesulphate PAROMOMYCIN SULFATE Paromomycin sulfate Synonyms fi5853 NEOMYCIN E aminosidinsulfate aminosidinesulfate aminosidinesulphate PAROMOMYCIN SULFATE Paromomycin sulfate Paromomycin Sulphate Aminosidine Sulphate PAROMOMYCIN SULPHATE paromomycin sulphates Paromomycin sulfate salt PAROMOMYCIN SULFATE SALT 4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxyhexopyranosyl)-D-lyxofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxyhexopyranoside sulfate (salt) (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-α-D-glucopyranoside sulfate (salt)
CAS	1263-89-4
EINECS	215-031-7
Chemical Formula	C23H47N5O18S
Molecular Weight	713.71
inchi	InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22 1-5(2,3)4/h5-23,29-36H,1-4,24-28H2 (H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23? inchi InChI=1/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22 1-5(2,3)4/h5-23,29-36H,1-4,24-28H2 (H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23? /m1./s1
Package	10 mM * 1 mL;500 mg;1 g
Price	Email to quote
Descriptions	Paromomycin sulfate Paromomycin sulfate MedChemExpress (MCE) HY-B0956 1263-89-4 Aminosidine sulfate 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Paromomycin sulfate Paromomycin sulfate MedChemExpress (MCE) HY-B0956 1263-89-4 Aminosidine sulfate 99.93% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections. Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellular C. parvum forms by 99.5% in HCT-8 cells[2]. Paromomycin sulfate (oral gavage 50 mg/kg-200 mg/kg once daily for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected with C. parvum and only 10% of focal inflammation at 200 mg/kg[1]. Aminoglycoside Amebae \| \| \| \| \| \| \| \| \| \| [1]. Tony J Tavares, et al. Structure of the cytosine-cytosine mismatch in the thymidylate synthase mRNA binding site and analysis of its interaction with the aminoglycoside paromomycin. RNA. 2009 May 15(5):911-22. [Content Brief] [2]. Mohamed Mammeri, et al. Efficacy of chitosan, a natural polysaccharide, against Cryptosporidium parvum in vitro and in vivo in neonatal mice. Exp Parasitol. 2018 Nov 194:1-8. [Content Brief] [3]. Ibrahim Aly, et al. Efficacy of Low and High Dose of Paromomycin Sulfate for Treatment of Cryptosporidiosis in Immunosuppressed Infected-Mice.Global Veterinaria 15 (2): 137-143, 2015
Last Update	2025-04-01 14:45:47

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