Lobeline hydrochloride MedChemExpress (MCE)

Product Name	(-)-Lobeline Hydrochloride
Synonyms	(-)-id Lobeline HCL Lobelinhydrochloride Lobelin Hydrochlorde Lobeline hydrochloride (-)-Lobeline Hydrochloride alpha-Lobeline hydrochloride Synonyms (-)-id Lobeline HCL Lobelinhydrochloride Lobelin Hydrochlorde Lobeline hydrochloride (-)-Lobeline Hydrochloride alpha-Lobeline hydrochloride butane-1,4-diyl dimethanesulfonate 2-[6-(2-HYDROXY-2-PHENETHYL)-1-METHYL-2-PIPERIDYL]ACETOPHENONE HCL 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor 2-(6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl)acetophenone hydrochloride 2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone 2-[6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-Acetophenone 2-{(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone 2-(6-[2-HYDROXY-2-PHENYLETHYL]-1-METHYL-2-PIPERIDINYL)-1-PHENYLETHANONE HYDROCHLORIDE 2-((2R,6S)-6-((S)-2-Hydroxy-2-Phenylethyl)-1-Methylpiperidin-2-Yl)-1-Phenylethanone Hydrochloride 2-{(2R,6S)-6-[(2R)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanone hydrochloride
CAS	134-63-4
EINECS	205-150-2
Chemical Formula	C22H28ClNO2
Molecular Weight	373.92
inchi	InChI=1/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H/t19-,20+,21+;/m0./s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Lobeline hydrochloride Lobeline hydrochloride MedChemExpress (MCE) HY-B0979 134-63-4 α-Lobeline hydrochloride Descriptions Lobeline hydrochloride Lobeline hydrochloride MedChemExpress (MCE) HY-B0979 134-63-4 α-Lobeline hydrochloride L-Lobeline hydrochloride 99.98% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation. Lobeline (0.1-100 μM) hydrochloride evokes [3H]DA overflow calcium-independently[1]. Lobeline hydrochloride inhibits [3H]DA uptake into synaptosomes (IC50=80 μM) and vesicles (IC50=0.88 μM)[1]. Lobeline (0.3-3.0 mg/kg s.c. single dose) hydrochloride decreases d-methamphetamine self-administration in rats model[3]. Lobeline (3 mg/kg s.c. 7 times during 7 sessions) hydrochloride specifically decreases responding for d-Methamphetamine in a noncompetitive manner, and increases tolerance development[3]. \| \| \| \| \| \| \| \| \| \| [1]. Teng L, et al. Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 1997 Mar 280(3):1432-44. [Content Brief]* [2]. Monzurul Amin Roni, et al. Lobeline attenuates ethanol abstinence-induced depression-like behavior in mice. Alcohol. 2017 Jun:61:63-70. [Content Brief] [3]. Harrod SB, et al. Lobeline attenuates d-methamphetamine self-administration in rats. J Pharmacol Exp Ther. 2001 Jul 298(1):172-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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