Cotinine MedChemExpress (MCE)

Product Name	(-)-cotinine
Synonyms	COTININE L-COTININE (-)-cotinine (-)-COTININE S-(-)-COTININE Nicotine EP Impurity C ( Cotinine) S(-)-1-METHYL-5-(3-PYRIDYL)-2-PYRROLIDONE Synonyms COTININE L-COTININE (-)-cotinine (-)-COTININE S-(-)-COTININE Nicotine EP Impurity C ( Cotinine) S(-)-1-METHYL-5-(3-PYRIDYL)-2-PYRROLIDONE [S]-1-METHYL-5-[3-PYRIDYL]-2-PYRROLIDINONE (5R)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one (S)-(-)-1-Methyl-5-(3-pyridyl)-2-pyrrolidinone (5S)-1-methyl-5-(pyridin-3-yl)pyrrolidin-2-one (S)-(-)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE
CAS	486-56-6
EINECS	207-634-9
Chemical Formula	C10H12N2O
Molecular Weight	176.22
inchi	InChI=1/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Cotinine Cotinine MedChemExpress (MCE) HY-B1178 486-56-6 (-)-Cotinine Descriptions Cotinine Cotinine MedChemExpress (MCE) HY-B1178 486-56-6 (-)-Cotinine (S)-Cotinine NIH-10498 98.46% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases. Mixture of Cotinine and Nicotine (2 μM Cotinine + 0.15 μM Nicotine, 7 days) retards the proliferation rate of human primary pterygium cells[4]. (S)-(-)-Cotinine (1–100 μM) was inhibited by the nicotinic receptor antagonists Mecamylamine (HY-B1395A) and Dihydro-β-erythroidine (HY-N10497) in the inhibition of dopamine release from rat striatal slices[5]. (S)-(-)-Cotinine (10–1000 μM) was inhibited in the release of dopamine from rat striatal slices by treatment with a low calcium buffer[5]. Cotinine (1 mg/kg (Nicotine), i.v., sampled at 5-60 min after administration) has a long biological half-life (19-24 hours) in Sprague-Dawley rats and is retained and accumulated in plasma for an extended period[2]. \| \| \| \| \| \| \| \| \| \| [1]. Dolcini MM, et al. An assessment of the validity of adolescent self-reported smoking using three biological indicators. Nicotine Tob Res. 2003 Aug 5(4):473-83. [Content Brief]* [2]. Sastry BV, et al. Distribution and retention of nicotine and its metabolite, cotinine, in the rat as a function of time. Pharmacology. 1995 Feb 50(2):128-36. [Content Brief] [3]. Borzelleca J F, et al. Studies on the respiratory and cardiovascular effects of (-)-cotinine[J]. Journal of Pharmacology and Experimental Therapeutics, 1962, 137(3): 313-318. [Content Brief] [4]. Yang Q, et al. Continuous exposure of nicotine and cotinine retards human primary pterygium cell proliferation and migration. [Content Brief] [5]. Dwoskin L P, et al. (S)-(−)-Cotinine, the major brain metabolite of nicotine, stimulates nicotinic receptors to evoke [3H] dopamine release from rat striatal slices in a calcium-dependent manner[J]. Journal of pharmacology and experimental therapeutics, 1999, 288(3): 905-911. [Content Brief]
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Last Update	2025-05-21 16:50:25

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