2-(Methylamino)-1H-purin-6(7H)-one MedChemExpress (MCE)

Product Name	6-HYDROXY-2-METHYLAMINOPURINE
Synonyms	N2-METHYLGUANINE 2-(MethylaMino)-7H-purin-6-ol 6-HYDROXY-2-METHYLAMINOPURINE 2-(MethylaMino)-1H-purin-6(7H)-one 2-methylamino-3,7-dihydropurin-6-one 1,7-Dihydro-2-(methylamino)-6H-purin-6-one Synonyms N2-METHYLGUANINE 2-(MethylaMino)-7H-purin-6-ol 6-HYDROXY-2-METHYLAMINOPURINE 2-(MethylaMino)-1H-purin-6(7H)-one 2-methylamino-3,7-dihydropurin-6-one 1,7-Dihydro-2-(methylamino)-6H-purin-6-one 2-(methylamino)-6,7-dihydro-3H-purin-6-one 6H-Purin-6-one,1,9-dihydro-2-(methylamino)-
CAS	10030-78-1
EINECS
Chemical Formula	C6H7N5O
Molecular Weight	165.15
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	2-(Methylamino)-1H-purin-6(7H)-one 2-(Methylamino)-1H-purin-6(7H)-one MedChemExpress (MCE) HY-101412 10030-78-1 N2-methylguanine 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions 2-(Methylamino)-1H-purin-6(7H)-one 2-(Methylamino)-1H-purin-6(7H)-one MedChemExpress (MCE) HY-101412 10030-78-1 N2-methylguanine 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. 2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding[1]. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min[2]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Rife JP, et al. N 2-methylguanosine is iso-energetic with guanosine in RNA duplexes and GNRA tetraloops. Nucleic Acids Res. 1998 Aug 15 26(16):3640-4. [Content Brief] [2]. Youvan DC, et al. Reverse transcriptase pauses at N2-methylguanine during in vitro transcription of Escherichia coli 16S ribosomal RNA. Proc Natl Acad Sci U S A. 1979 Aug 76(8):3751-4. [Content Brief]
Supplier Website	https://www.medchemexpress.com/N2-Methylguanine.html
Last Update	2025-05-21 16:50:25

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