Coproporphyrin III MedChemExpress (MCE)

Product Name	COPROPORPHYRIN III DIHYDROCHLORIDE
Synonyms	COPROPORPHYRIN III DIHYDROCHLORIDE
CAS	14643-66-4
EINECS
Chemical Formula	C36H40Cl2N4O8
Molecular Weight	654.71
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Coproporphyrin III Coproporphyrin III MedChemExpress (MCE) HY-101398 14643-66-4 Zincphyrin 98.71% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years Descriptions Coproporphyrin III Coproporphyrin III MedChemExpress (MCE) HY-101398 14643-66-4 Zincphyrin 98.71% 4°C, sealed storage, away from moisture In solvent : -80°C, 2 years -20°C, 1 year (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Coproporphyrin III (Zincphyrin) is a naturally occurring porphyrin derivative that is mainly found in urine. Coproporphyrin III methyl ester is repeatedly isolated in considerable amount from both feces and urine. A great increase of coproporphyrin III excretion is unaccompanied by symptoms or signs of porphyria, metal or chemical poisoning or liver disease[1]. Primary cultures of chick embryo hepatocytes have been used to study the mechanism by which chemicals cause accumulation of intermediates of the heme synthetic pathway. In the presence of the porphyrin precursor, 5-aminolevulinate (ALA), addition of insulin causes a striking increase in accumulation of uroporphyrin I and coproporphyrin III. Antioxidants abolishes the uroporphyrin I accumulation and increases coproporphyrin III[2]. Urinary DMA and porphyrin profile can be used as an early warning biomarker for chronic MMA exposure before the onset of cancer. After 4 weeks the level of coproporphyrin III concentration significantly increases in all the treatment groups compared to the control[3]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Watson CJ, et al. Studies of coproporphyrin. iii. idiopathic coproporphyrinuria a hitherto unrecognized form characterized by lack of symptoms in spite of the excretion of large amounts of coproporphyrin. J Clin Invest. 1949 May 28(3):465-8. [Content Brief] [2]. Trask HW, et al. Effect of insulin and glucagon on accumulation of uroporphyrin and coproporphyrin from 5-aminolevulinate in hepatocyte cultures. Arch Biochem Biophys. 2005 Jul 1 439(1):1-11. [Content Brief] [3]. Krishnamohan M, et al. Urinary arsenic and porphyrin profile in C57BL/6J mice chronically exposed to monomethylarsonous acid (MMAIII) for two years. Toxicol Appl Pharmacol. 2007 Oct 1 224(1):89-97. [Content Brief]
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Last Update	2025-04-01 14:45:47

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