Pembrolizumab MedChemExpress (MCE)

Product Name	Lambrolizumab
Synonyms	Lambrolizumab;Pembrolizumab;pembrolimumab;Pembrolizumab (anti-PD-1);PEMBROLIMUMAB PD-1 1374853-91-4
CAS	1374853-91-4
EINECS	807-012-2
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Pembrolizumab Pembrolizumab MedChemExpress (MCE) HY-P9902 1374853-91-4 MK-3475 Descriptions Pembrolizumab Pembrolizumab MedChemExpress (MCE) HY-P9902 1374853-91-4 MK-3475 Lambrolizumab 99.17% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy. Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells[2].Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells[2]. Pembrolizumab inhibits tumor size in A549 xenograft mice pretreated by pressure[2]. IC50: 0.6 nM (PD-1) In Vitro Pembrolizumab (MK-3475) increases the secretion of cytokines IFN-γ, TNF-α and the apoptotic cell death of A549 cells[2].Pembrolizumab improves the αROR1-CAR T-mediated cytotoxicity, and reduces tumorigenesis in the co-cultured αROR1-CAR T and A549 cells by blocking PD-1::PD-L1 interaction in αROR1-CAR T cells[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Pembrolizumab Related Antibodies Cell Cytotoxicity Assay[2] Cell Line: αROR1-CAR T and A549 cells Humanized Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Amita Patnaik, et al. Phase I Study of Pembrolizumab (MK-3475 Anti–PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors. Clin Cancer Res.2015Oct1 21(19):4286-93. [Content Brief] [2]. Zhenglin Ou, et al. Pressure increases PD‑L1 expression in A549 lung adenocarcinoma cells and causes resistance to anti‑ROR1 CAR T cell‑mediated cytotoxicity, Sci Rep [Content Brief] [3]. Amita Patnaik, et al. Phase I Study of Pembrolizumab (MK-3475 Anti–PD-1 Monoclonal Antibody) in Patients with Advanced Solid Tumors. Clin Cancer Res.2015Oct1 21(19):4286-93. [4]. Schachter J, et al. Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet. 2017 Aug 16. pii: S0140-6736(17)31601-X. [Content Brief]
Last Update	2025-04-01 14:45:47

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