Nivolumab MedChemExpress (MCE)

Product Name	Nivolumab
Synonyms	Opdivo;ONO 4538;MDX 1106;Nivolumab;BMS 936558;Nivolumab (anti-PD-1)
CAS	946414-94-4
EINECS
Chemical Formula
Molecular Weight
inchi
Package	25 mg;25 mg;50 mg;50 mg;1 mg;1 mg;5 mg;5 mg;10 mg;10 mg
Price	Email to quote
Descriptions	Nivolumab Nivolumab MedChemExpress (MCE) HY-P9903 946414-94-4 BMS-936558 Descriptions Nivolumab Nivolumab MedChemExpress (MCE) HY-P9903 946414-94-4 BMS-936558 ONO-4538 MDX-1106 99.63% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Nivolumab is a programmed death receptor-1 (PD-1) blocking human IgG4 antibody to treat advanced (metastatic) non-small cell lung cancer. Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus[1]. Nivolumab (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted[1]. Human Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Wang C, et al. In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res. 2014 Sep 2(9):846-56. [Content Brief]
Last Update	2025-04-01 14:45:47

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