(+)-Catechin hydrate MedChemExpress (MCE)

Product Name	(+)-Catechin Hydrate
Synonyms	EU-0067758 BAS 00381104 FK-027-13C,15N2 FR- 17027-13C,15N2 (+)-Catechin Hydrate (+)-CATECHIN HYDRATE (2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate Synonyms EU-0067758 BAS 00381104 FK-027-13C,15N2 FR- 17027-13C,15N2 (+)-Catechin Hydrate (+)-CATECHIN HYDRATE (2R,3S)-2-(3,4-Dihydroxyphenyl)-chroman-3,5,7-triol hydrate 4-methyl-2-oxo-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester 2-keto-4-methyl-6-phenyl-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester
CAS	225937-10-0
EINECS	684-232-3
Chemical Formula	C15H16O7
Molecular Weight	308.29
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Package	5 mg;5 mg;10 mg;10 mg;25 mg;25 mg;50 mg;50 mg;100 mg;100 mg
Price	Email to quote
Descriptions	(+)-Catechin hydrate (+)-Catechin hydrate MedChemExpress (MCE) HY-N0355 225937-10-0 99.59% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions (+)-Catechin hydrate (+)-Catechin hydrate MedChemExpress (MCE) HY-N0355 225937-10-0 99.59% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. (+)-Catechin hydrate inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (+)-Catechin exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM[1]. A dose-dependent reduction in color is observed after 24 hours of treatment with (+)-Catechin, and 54.76% of the cells are dead at the highest concentration of (+)-Catechin tested (160 μg/mL) whereas the IC50 of (+)-Catechin is achieved at 127.62 μg/mL (+)-Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with (+)-Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL (+)-Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL (+)-Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells[2]. Animals treated with (+)-Catechin at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. (+)-Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with (+)-Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively)[3]. Rats[3] Twelve weeks old, healthy male rats weighing 200 to 230 g are used in this study. Rats are divided into four experimental groups (n=9 each) for one vehicle and three groups of (+)-Catechin (three doses). The doses of (+)-Catechin are prepared at 50, 100, 200 mg/kg and administered orally for 7 days prior to and during the experimental trials. Episodic memory, the conscious memory of the past experiences is evaluated in this study[3]. The Cell viability assay is performed to assess the toxicity of different concentrations of (+)-Catechin on MCF-7 cells. Briefly, MCF-7 cells (2×104 cells/well) are plated in 96-well plates and treated with 0 μg/mL (+)-Catechin and 160 μg/mL (+)-Catechin for 24 hours. Then, 40 μL of the Cell Titer Blue solution is directly added to the wells and incubated at 37°C for 6 hours. The fluorescence is recorded with a 560 nm/590 nm (excitation/emission) filter set using a microplate fluorescence reader, and the IC50 is calculated. Quadruplet samples are run for each concentration of (+)-Catechin in three independent experiments[2]. COX-1 1.4 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001 40(2):173-9. [Content Brief] [2]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17 29:167. [Content Brief] [3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb 70(1):245-259. [Content Brief]
Last Update	2025-04-01 14:45:47

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