Nicotiflorin MedChemExpress (MCE)

Product Name	Kaempferol-3-O-rutinoside
Synonyms	NICOTIFLORIN Nictoflorin (incorr Kaempferol-3-O-rutinosid Aempferol-3-O-rutinoside Kaempferol-3-O-rutinoside KaeMpferol-3-O-rutinoside, Nicotiflorin 3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside Synonyms NICOTIFLORIN Nictoflorin (incorr Kaempferol-3-O-rutinosid Aempferol-3-O-rutinoside Kaempferol-3-O-rutinoside KaeMpferol-3-O-rutinoside, Nicotiflorin 3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius 4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-Mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
CAS	17650-84-9
EINECS
Chemical Formula	C27H30O15
Molecular Weight	594.52
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Nicotiflorin Nicotiflorin MedChemExpress (MCE) HY-N1475 17650-84-9 99.82% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Nicotiflorin Nicotiflorin MedChemExpress (MCE) HY-N1475 17650-84-9 99.82% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects. For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron[2]. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions[3]. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits[2]. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits[3]. Rats[2] A neurological examination is performed on each rat 24 h after the onset of ischemia. Briefly, neurological scores (NS) are derived using a 10-point sliding scale. Rats are administered 2.5, 5, and 10 mg/kg nicotiflorin or vehicle immediately after occlusion. Each animal is examined for reduced resistance to lateral push (score, 4), open field circling (score, 3), and shoulder adduction (score, 2) or contralateral forelimb flexion (score, 1) when held by the tail and suspended approximately 0.5 m above the floor. Rats extending both forelimbs toward the floor and not showing any other signs of neurological impairment are scored 0[2]. Cortical neurons are treated with nicotiflorin (25-100 mg/mL) just before hypoxia. Cell viability is determined using the MTT assay[2]. Antiglycation[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Lal Shyaula S, et al. Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin). Med Chem. 2012 May 8(3):415-20. [Content Brief] [2]. Li R, et al. Neuroprotection of nicotiflorin in permanent focal cerebral ischemia and in neuronal cultures. Biol Pharm Bull. 2006 Sep 29(9):1868-72. [Content Brief] [3]. Wang L, Li C, Guan C, et al. Nicotiflorin attenuates cell apoptosis in renal ischemia-reperfusion injury through activating transcription factor 3. Nephrology (Carlton). 2021 26(4):358-368. [Content Brief] [4]. Yu S, Guo Q, Jia T, et al. Mechanism of Action of Nicotiflorin from Tricyrtis maculata in the Treatment of Acute Myocardial Infarction: From Network Pharmacology to Experimental Pharmacology. Drug Des Devel Ther. 2021 15:2179-2191. [Content Brief]
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Last Update	2025-05-21 16:50:25

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