D-Lin-MC3-DMA MedChemExpress (MCE)

Product Name	DLin-M-C3-DMA
Synonyms	DLINMC3DMA DLin-M-C3-DMA D-LIN-MC3-DMA D-Lin-MC3-DMA D-LIN-MC-3-DMA D-Lin-MC3-DMA (MC3) dilinoleylmethyl 4-(dimethylamino)butanoate Synonyms DLINMC3DMA DLin-M-C3-DMA D-LIN-MC3-DMA D-Lin-MC3-DMA D-LIN-MC-3-DMA D-Lin-MC3-DMA (MC3) dilinoleylmethyl 4-(dimethylamino)butanoate O-(Z,Z,Z,Z-heptatriaconta-6,9,26,29-tetraen-19-yl)-4-(N,N-dimethylamino) (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate Butanoic acid, 4-(dimethylamino)-, (10Z,13Z)-1-(9Z,12Z)-9,12-octadecadien-1-yl-10,13-nonadecadien-1-yl ester
CAS	1224606-06-7
EINECS
Chemical Formula	C43H79NO2
Molecular Weight	642.09
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	D-Lin-MC3-DMA D-Lin-MC3-DMA MedChemExpress (MCE) HY-112251 1224606-06-7 99.68% -20°C, protect from light In solvent : -80°C, 6 months Descriptions D-Lin-MC3-DMA D-Lin-MC3-DMA MedChemExpress (MCE) HY-112251 1224606-06-7 99.68% -20°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. Preparation of MC3 Lipid Nanoparticles Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1]. \| \| \| \| \| \| \| \| \| \| [1]. Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May 13(4):1377-1387. [Content Brief] [2]. Ferraresso F, Strilchuk AW, Juang LJ, Poole LG, Luyendyk JP, Kastrup CJ. Comparison of DLin-MC3-DMA and ALC-0315 for siRNA Delivery to Hepatocytes and Hepatic Stellate Cells. Mol Pharm. 2022 19(7):2175-2182. [Content Brief]
Supplier Website	https://www.medchemexpress.com/D-Lin-MC3-DMA.html
Last Update	2025-05-21 16:50:25

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