Exendin-3 MedChemExpress (MCE)

Product Name	Exendin-3
Synonyms	Exendin-3 EXENDIN-3 M.W. 4202.57 C184H282N50O61S HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 HIS-SER-ASP-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 Synonyms Exendin-3 EXENDIN-3 M.W. 4202.57 C184H282N50O61S HSDGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 HIS-SER-ASP-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 H-HIS-SER-ASP-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
CAS	130357-25-4
EINECS
Chemical Formula	C184H282N50O61S
Molecular Weight	4202.57128
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Exendin-3 Exendin-3 MedChemExpress (MCE) HY-P1543 130357-25-4 98.31% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions Exendin-3 Exendin-3 MedChemExpress (MCE) HY-P1543 130357-25-4 98.31% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) Room temperature in continental US may vary elsewhere. Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn. Exendin-3 interacts with at least two receptors on guinea pig pancreatic acini at high concentrations (>100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function[1]. Effect of increasing concentrations of two VIP receptor antagonists on the increase in amylase release are observed with VIP, secretin, or exendin-3. Male Hartley guinea pigs Acini were incubated with VIP (1 nM), secretin (1 μM), or Exendin-3 (1 μM) for 30 min at 37°C, alone or in combination with indicated concentrations of [AcTyr, D-Phe]GRF 1-29 amide (solid symbols) or [4-Cl-D-Phe,Leu] VIP (open symbols)[1]. VIP receptor, putative exendin receptor[1] In Vitro Exendin-3 interacts with at least two receptors on guinea pig pancreatic acini at high concentrations (>100 nM) the peptide interacts with VIP receptors, thereby causing a large increase in cAMP and stimulating amylase release at lower concentrations (0.1-3 nM) the peptide interacts with a putative exendin receptor, thereby causing a smaller increase in cAMP of undetermined function[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Exendin-3 Related Antibodies His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 \| \| \| \| \| \| \| \| \| \| [1]. Raufman JP, et al. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J Biol Chem. 1991 Feb 15 266(5):2897-902. [Content Brief]
Last Update	2025-04-01 14:45:47

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