PalmitoylethanolamidePalmitoylethanolamide
MedChemExpress (MCE)
HY-20685
544-31-0
Palmidrol
Loramine P 256
99.94%
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Room temperature in continental US
may vary elsewhere.
Palmitoylethanolamide (Palmidrol) is an active endogenous compound which can used for preventing virus infection of the respiratory tract.
Palmitoylethanolamide (Palmidrol) itself does not stimulate interferon production in mice treated per os or intravenously. But repeated application of this drug per os induces a macrophage activation, reflected by enhanced interferon production in vitro. When the interferon stimulation is delayed until 4 to 10 days after the first dose of Palmitoylethanolamide, interferon response to ds-RNA is slightly increased. After this phase of enhanced activity a decreased production of interferon is observed. Palmitoylethanolamide is not significantly effective in protecting mice from lethal dose of EMC virus. Application of this drug has an inhibitory effect on the toxicity of ds-RNA. A possible explanation of the mechanism by which Palmitoylethanolamide decreased the toxicity of virus in the organism is discussed[1].
Human Endogenous Metabolite
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[1]. Lackovic V, et al. Effect of impulsin treatment of interferon production and antiviral resistance of mice. Arch Immunol Ther Exp (Warsz). 1977
25(5):655-61. [Content Brief]