5'-Methylthioadenosine MedChemExpress (MCE)

Product Name	5'-DEOXY-5'-METHYLTHIOADENOSINE
Synonyms	NSC 335422 5'-S-Methyl-5'-thioadenosine 5'-Deoxy(Methylthio)adenosine 5'-DEOXY-5'-METHYLTHIOADENOSINE 7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol Synonyms NSC 335422 5'-S-Methyl-5'-thioadenosine 5'-Deoxy(Methylthio)adenosine 5'-DEOXY-5'-METHYLTHIOADENOSINE 7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol 7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine
CAS	2457-80-9
EINECS
Chemical Formula	C11H15N5O3S
Molecular Weight	297.33
inchi
Package	10 mM * 1 mL;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	5'-Methylthioadenosine 5'-Methylthioadenosine MedChemExpress (MCE) HY-16938 2457-80-9 5'-(Methylthio)-5'-deoxyadenosine Descriptions 5'-Methylthioadenosine 5'-Methylthioadenosine MedChemExpress (MCE) HY-16938 2457-80-9 5'-(Methylthio)-5'-deoxyadenosine 5'-Deoxy-5'-(methylthio)adenosine 5'-S-Methyl-5'-thioadenosine 99.71% -20°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis. 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis. 5'-Methylthioadenosine protects MTAP+ cells significantly better than MTAP cells from 6TG (6′-thioguanine) toxicity[3]. The 2FA (2′-fluoroadenine) + MTA (5'-Methylthioadenosine) combination (100 mg/kg MTA 20 mg/kg 2FA) inhibits tumor growth of four different MTAP human tumor cell lines in mouse xenograft models[3]. Human Endogenous Metabolite Microbial Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Yaofeng Li, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019 10(4):927-936. [Content Brief]* [2]. Tang Y, et al. 5'-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014 37(5):1366-1373. [Content Brief] [3]. Li Y, et al. 5'-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019 10(4):927-936. [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2'-Fluoroadenine and 5'-Methylthioadenosine. Cancer Res. 2018 78(15):4386-4395. [Content Brief]
Last Update	2025-04-01 14:45:47

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