Adapalene-d3 MedChemExpress (MCE)

Product Name	Adapalene-d3
Synonyms	CD-271-d3;Differin-d3;Adapalene-d3;Adapalene-(methoxy-d3);6-[3-(1-AdaMantyl)-4-(Methoxy-d3)phenyl]-2-naphthoic Acid;6-[4-(Methoxy-d3)-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl]-2-naphthalenecarboxylic Acid
CAS	1276433-89-6
EINECS
Chemical Formula	C28H28O3
Molecular Weight	412.52012
inchi
Package	500 μg
Price	Email to quote
Descriptions	Adapalene-d3 Adapalene-d3 MedChemExpress (MCE) HY-B0091S 1276433-89-6 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Adapalene-d3 Adapalene-d3 MedChemExpress (MCE) HY-B0091S 1276433-89-6 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Adapalene-d3 is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Shroot B, et, al. Pharmacology and chemistry of adapalene. J Am Acad Dermatol. 1997 Jun 36(6 Pt 2):S96-103. [Content Brief] [3]. Wang Q, et, al. Adapalene inhibits ovarian cancer ES-2 cells growth by targeting glutamic-oxaloacetic transaminase 1. Bioorg Chem. 2019 Dec 93:103315. [Content Brief] [4]. Shi XN, et, al. Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma. Mol Med Rep. 2015 Nov 12(5):6501-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/adapalene-d3.html
Last Update	2025-05-21 16:50:25

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