Serotonin hydrochloride MedChemExpress (MCE)

Product Name	Serotonin hydrochloride
Synonyms	5-HT Serotonin HCL SEROTONIN HCL TIMTEC-BB SBB003418 SEROTONINEHYDROCHLORIDE Serotonin hydrochloride SERATONIN HYDROCHLORIDE Synonyms 5-HT Serotonin HCL SEROTONIN HCL TIMTEC-BB SBB003418 SEROTONINEHYDROCHLORIDE Serotonin hydrochloride SERATONIN HYDROCHLORIDE 5-Hydroxytryptamine HCL Seratonin hydrochloride SEROTONIN HYDROCHLORIDE(RG) 5-Hydroxytryptamine hydrochloride 3-(2-Aminoethyl)-5-hydroxyindole hydrochloride 5-Hydroxy-3-(2-Aminoethyl)INDOLE hydrochloride Serotonin hydrochloride,3-(2-Aminoethyl)-5-hydroxyindole hydrochloride, 5-HT, 5-Hydroxytryptamine hydrochloride
CAS	153-98-0
EINECS	628-480-2
Chemical Formula	C10H13ClN2O
Molecular Weight	212.68
inchi	InChI=1/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H
Package	10 mM * 1 mL;10 mM * 1 mL;50 mg;50 mg;100 mg;100 mg;250 mg;250 mg
Price	Email to quote
Descriptions	Serotonin hydrochloride Serotonin hydrochloride MedChemExpress (MCE) HY-B1473 153-98-0 5-Hydroxytryptamine hydrochloride Descriptions Serotonin hydrochloride Serotonin hydrochloride MedChemExpress (MCE) HY-B1473 153-98-0 5-Hydroxytryptamine hydrochloride 5-HT hydrochloride 99.97% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT[1]. Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p[1]. A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis[2]. Dextran sodium sulfate (DSS) colitis is induced by orally administering 5% DSS in drinking water for 5 days. In a separate experiment, IL-13-/- mice are injected subcutaneously with 100 mg/kg of Serotonin hydrochloride (5-HTP) twice daily for 8 days beginning 3 days prior to induction of DSS colitis whereas, the control IL-13-/- mice receive saline as vehicle. Animals are anaesthetized prior to euthanization via cervical dislocation at the conclusion of each experiment or if they reach a predetermined end point (ie, loss of ≥20% body weight and/or significant deterioration of body condition)[2]. For macrophage culture, peritoneal cavity cells are collected from WT and IL-13-/- mice with or without dextran sodium sulfate (DSS) treatment and cultured. Cells are plated at a concentration of 3.0×106 cells per millilitre, and treated with either lipopolysaccharides (LPS) (100 ng/mL) or Serotonin hydrochloride (10-10 M) for 24 hours. The culture supernatant are collected and stored in -80°C until determination of cytokine levels using protein array system[2]. Human Endogenous Metabolite Microbial Metabolite serotonin \| \| \| \| \| \| \| \| \| \| [1]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13 8:25. [Content Brief]* [2]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28 8(8):e72774. [Content Brief]
Last Update	2025-04-01 14:45:47

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