Tolcapone-d4 MedChemExpress (MCE)

Product Name	Tolcapone-d4
Synonyms	TasMar-d4;Tolcapone-d4;Ro-40-7592-d4;(3,4-Dihydroxy-5-nitrophenyl)(4-Methylphenyl-d4)Methanone
CAS	1246816-93-2
EINECS
Chemical Formula	C14H11NO5
Molecular Weight	273.24084
inchi
Package	1 mg
Price	Email to quote
Descriptions	Tolcapone-d4 Tolcapone-d4 MedChemExpress (MCE) HY-17406S1 1246816-93-2 Ro 40-7592-d4 99.13% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Tolcapone-d4 Tolcapone-d4 MedChemExpress (MCE) HY-17406S1 1246816-93-2 Ro 40-7592-d4 99.13% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Tolcapone-d4 is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver[1]. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. C De Santi, et al. Eur J Clin Pharmacol. 1998 May 54(3):215-9. [Content Brief] [3]. Saviana Di Giovanni, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14 285(20):14941-14954. [Content Brief] [4]. Tyler Maser,et al. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in Neuroblastoma.Cancer Med. 2017 Jun 6(6):1341-1352. [Content Brief]
Supplier Website	https://www.medchemexpress.com/tolcapone-d4.html
Last Update	2025-05-21 16:50:25

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