Camptothecin-d5 MedChemExpress (MCE)

Product Name	(S)-(+)-CaMptothecin-d5
Synonyms	(S)-(+)-CaMptothecin-d5
CAS	1329616-37-6
EINECS
Chemical Formula	C20H16N2O4
Molecular Weight	348.35204
inchi
Package	1 mg
Price	Email to quote
Descriptions	Camptothecin-d5 Camptothecin-d5 MedChemExpress (MCE) HY-16560S 1329616-37-6 Campathecin-d5 Descriptions Camptothecin-d5 Camptothecin-d5 MedChemExpress (MCE) HY-16560S 1329616-37-6 Campathecin-d5 (S)-(+)-Camptothecin-d5 CPT-d5 99.61% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Camptothecin-d5 is the deuterium labeled Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells[2][3]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief]* [2]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. [Content Brief] [3]. Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Mol Cancer Ther. 2014 13(1):239-248. [Content Brief] [4]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013 63:746-757. [Content Brief] [5]. Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019 19(1):1158. Published 2019 Nov 29. [Content Brief] [6]. Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. J Natl Cancer Inst. 2008 100(12):862-875.. [Content Brief]
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Last Update	2025-05-21 16:50:25

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