7,8-Dihydroxyflavone MedChemExpress (MCE)

Product Name	7,8-Dihydroxyflavone
Synonyms	8-Dihydroxyflavone 7,8-Dihydroxyflavone 7,8-DIHYDROXYFLAVONE DIHYDROXYFLAVONE, 7,8-(RG) 7,8-Dihydroxyflavone7,8-DHF 7,8-Dihydroxyflavone hydrate 7,8-dihydroxy-2-phenyl-4-benzopyrone Synonyms 8-Dihydroxyflavone 7,8-Dihydroxyflavone 7,8-DIHYDROXYFLAVONE DIHYDROXYFLAVONE, 7,8-(RG) 7,8-Dihydroxyflavone7,8-DHF 7,8-Dihydroxyflavone hydrate 7,8-dihydroxy-2-phenyl-4-benzopyrone 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE
CAS	38183-03-8
EINECS	253-812-4
Chemical Formula	C15H10O4
Molecular Weight	254.24
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Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;500 mg
Price	Email to quote
Descriptions	7,8-Dihydroxyflavone 7,8-Dihydroxyflavone MedChemExpress (MCE) HY-W013372 38183-03-8 99.90% 4°C, stored under nitrogen In solvent : -80°C, 1 year Descriptions 7,8-Dihydroxyflavone 7,8-Dihydroxyflavone MedChemExpress (MCE) HY-W013372 38183-03-8 99.90% 4°C, stored under nitrogen In solvent : -80°C, 1 year -20°C, 6 months (stored under nitrogen) Room temperature in continental US may vary elsewhere. 7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases. 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1]. Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2]. TrkB \| \| \| \| \| \| \| \| \| \| [1]. Zhang Z, et al. 7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology. 2014 Feb 39(3):638-50. [Content Brief]
Last Update	2025-04-01 14:45:47

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