Acetyl-L-carnitine hydrochlorideAcetyl-L-carnitine hydrochloride
MedChemExpress (MCE)
HY-B0762
5080-50-2
O-Acetyl-L-carnitine hydrochloride
ALCAR hydrochloride
99.95%
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months
-20°C, 1 month (sealed storage, away from moisture)
Room temperature in continental US
may vary elsewhere.
Acetyl-L-carnitine (O-Acetyl-L-carnitine) hydrochloride is a blood-brain permeable acetyl ester of the amino acid L-carnitine with anti-apoptotic effects. Acetyl-L-carnitine hydrochloride promotes neuronal survival and mitochondrial activity, attenuates DNA fragmentation and nuclear condensation in cultured neurons and signifcantly decreases histone-DNA release into the cytoplasm. Acetyl-L-carnitine hydrochloride is often used as a dietary supplement, and is promising for research of stress-related psychiatric disorders.
Acetyl-L-carnitine hydrochloride (1-100 μM, 3 days) inhibits the cell death and mitochondrial activity in the cultured neurons from the cerebral cortex, striatum and thalamus[3]. Acetyl-L-carnitine hydrochloride (1-100 μM, 3 days) decreases the appearance of DNA laddering, DNA condensation and inhibits the release of histone-DNA complex into the cytoplasm in rat neuronal cells[3].
Acetyl-L-carnitine hydrochloride (0.1 mg/L, diluted in water, 10 min per day for 7 days) reverses unpredictable chronic stress (UCS)-induced anxiety-like behavior and oxidative damage in zebrafish[1].
Human Endogenous Metabolite
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[1]. Marcon M, et al. Acetyl-L-carnitine as a putative candidate for the treatment of stress-related psychiatric disorders: Novel evidence from a zebrafish model. Neuropharmacology. 2019 May 15
150:145-152. [Content Brief]
[2]. Weber H P, et al. Acetyl-l-carnitine Hydrochloride[J]. Acta Crystallographica Section C: Crystal Structure Communications, 1995, 51(12): 2570-2572.
[3]. Ishii T, et al. Anti-apoptotic effect of acetyl-l-carnitine and I-carnitine in primary cultured neurons. Jpn J Pharmacol. 2000 Jun
83(2):119-24. [Content Brief]