Polyphyllin VI MedChemExpress (MCE)

Product Name	Polyphyllin VI
Synonyms	Polyhyllin VI Polyphyllin Ⅵ Polyphyllin VI Paris saponin VI 17-Hydroxyparis V Chonglou saponin Ⅵ Polyphyllin F (Polyphyllin VI) Synonyms Polyhyllin VI Polyphyllin Ⅵ Polyphyllin VI Paris saponin VI 17-Hydroxyparis V Chonglou saponin Ⅵ Polyphyllin F (Polyphyllin VI) (2R,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((2'R,4S,5'R,6aR,6bS,8aS,8bS,9S,11aS,12
CAS	55916-51-3
EINECS
Chemical Formula	C39H62O13
Molecular Weight	738.9
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Polyphyllin VI Polyphyllin VI MedChemExpress (MCE) HY-N0816 55916-51-3 98.41% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Polyphyllin VI Polyphyllin VI MedChemExpress (MCE) HY-N0816 55916-51-3 98.41% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Polyphyllin VI (0-16 μM 48 h) significantly decreases the viability of A549, NCI-H1299 and HepaRG cells in a dose-dependent manner[1][2]. Polyphyllin VI (0.5-2 μM-1 μM 24 h) significantly increases the percentage of A549, and NCI-H1299 cells in the G2/M stage in a dose-dependent manner[1]. Polyphyllin VI (0-12 μM-1 μM 24 h) arrests HepaRG cells at S stage [2]. Polyphyllin VI (0-6 μM-1 μM 24 h) activates the NLRP3 inflammasome[3]. Polyphyllin VI (0-6 μM-1 μM 24 h) induces pyroptosis via ROS/NF-κB pathway om A549 and NCI-H1299 cells[3]. Polyphyllin VI (2-4 mg/kg i.p. five times a week for 4 weeks) inhibits the growth of lung cancer tumor xenografts[1]. Polyphyllin VI (2.5-10 mg/kg i.p. 10 consecutive days) activates NLRP3 inflammasome in A549-bearing athymic nude mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct 29(10):1568-76. [Content Brief] [2]. Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15 10(5). pii: E201. [Content Brief] [3]. Jin-Feng Teng, et al. Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer. Cancers (Basel). 2020 Jan 13 12(1):193. [Content Brief]
Last Update	2025-04-01 14:45:47

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