Ajmalicine MedChemExpress (MCE)

Product Name	Ajmalicine
Synonyms	RAUBASIN Raubasine RAUBASINE Ajmalicine YOHIMBINE, C- 19-Epiajmalicine , 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- Synonyms RAUBASIN Raubasine RAUBASINE Ajmalicine YOHIMBINE, C- 19-Epiajmalicine , 7-[3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentyl]- methyl 19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate 16,17-didehydro-19-methyloxayohimban-16-carboxylicacidmethylester 16,17-Didehydro-19-methyloxayohimban-16-carboxylic acid methyl ester methyl (19alpha)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate 16,17-Didehydro-19alpha-methyloxayohimban-16-carboxylic acid methyl ester
CAS	483-04-5
EINECS	207-589-5
Chemical Formula	C21H24N2O3
Molecular Weight	352.43
inchi	InChI=1/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1
Package	1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Ajmalicine Ajmalicine MedChemExpress (MCE) HY-N1919 483-04-5 Raubasine 99.39% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Ajmalicine Ajmalicine MedChemExpress (MCE) HY-N1919 483-04-5 Raubasine 99.39% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity. Ajmalicine preferentially blocks α1-adrenoceptor than α2-adrenoceptor[1]. Ajmalicine inhibits contractions in a concentration-dependent manner (IC50=72.3 ± 22.5 μM)[2]. Ajmalicine acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[3]. Ajmalicine blocking the pressor action of electrical stimulation and is active against sympathetic stimulation[1]. Ajmalicine (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1]. α1-adrenergic receptor α2-adrenergic receptor \| \| \| \| \| \| \| \| \| \| [1]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30 106(1):203-5. [Content Brief] [2]. Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul 17(8-9):646-52. [Content Brief] [3]. Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct 83(2):505-10 [Content Brief]
Last Update	2025-04-01 14:45:47

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