Seconeolitsine MedChemExpress (MCE)

Product Name	INDEX NAME NOT YET ASSIGNED
Synonyms	INDEX NAME NOT YET ASSIGNED
CAS	2650074-56-7
EINECS
Chemical Formula	C19H17NO4
Molecular Weight	323.34
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Seconeolitsine Seconeolitsine MedChemExpress (MCE) HY-N10495 2650074-56-7 95.0% 4°C, stored under nitrogen In solvent : -80°C, 6 months Descriptions Seconeolitsine Seconeolitsine MedChemExpress (MCE) HY-N10495 2650074-56-7 95.0% 4°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. Seconeolitsine, an antibiotic, and is an inhibitor of targeting topoisomerase I (TopA). Seconeolitsine also is a new antimicrobial agent that can inhibit S. pneumoniae growth. Seconeolitsine can inhibit TopA relaxation activity with an IC50 value of 17 μM. Seconeolitsine can be used for the research of S. pneumoniae infections resistant to other antibiotics. Seconeolitsine (compounds 17) inhibits TopA relaxation activity in a concentration-dependent manner, with an IC50 value of 17 μM and the inhibition of TopA is enhanced by preincubation of the enzyme with the alkaloid[1]. Seconeolitsine shows great inhibition of S.pneumoniae growth with MIC50 values of 16 μM for R6, ATCC6303, CipS8, CipS9, CipR20, CipR16, CipR8, CipR45 and CipR5. And shows great inhibition of S. pneumoniae growth with MIC50 values of 8 μM for CipR42, CipR68 and CipR15[1]. Seconeolitsine has activation at low concentrations and partial inhibition at 50 μM, a concentration at which the pneumococcal TopA showed full inhibition, but not inhibits Human TOPO1[1]. Seconeolitsine (0.25×-1×MIC) affects cell growth and division in a concentration-dependent manner[1]. Seconeolitsine (30 and 100 μM), is not affected neutrophil apoptosis and human cell viability[1]. Seconeolitsine (compounds 17) increases supercoiling and TopA is target in vivo[1]. Topoisomerase I 17 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. María Teresa García, et al. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumonia. J Biol Chem. 2011 Feb 25 286(8):6402-13. [Content Brief]
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Last Update	2025-05-21 16:50:25

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