Polygalacturonic acidPolygalacturonic acid
MedChemExpress (MCE)
HY-N6613
25990-10-7
Galacturonic acid polymer
95.16%
4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)
Room temperature in continental US
may vary elsewhere.
Polygalacturonic acid (Galacturonic acid polymer) is transparent colloid, is a major component of the cell wall. Polygalacturonic acid can be used to prepare silver nanoparticles (AgNPs), as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. Polygalacturonic acid nanoparticles also displays anti-bacterial activity.
Polygalacturonic acid can be used to format a durable hydrogel, to prolong the effect of drugs. Polygalacturonic acid hydrogel/hyaluronate, conjugated Ibuprofen (HY-78131) for example, prevents epidural fibrosis, the severe scar tissue adhesion of laminectomized male adult rats, and increases the efficiency of local inflammation control and reduces the side-effect of Ibuprofen[1]. Polygalacturonic acid hydrogel/hyaluronate (PGA-HA) (2%, 200 μL
24 h) shows low cytotoxicity on L929 fibroblasts[1]. Polygalacturonic acid (PGA) preparing (Ag-PGA/HA)-PVA nanoparticles, shows anti-bacterial activity against gram-positive bacterial strains
Bacillus Subtilis and Staphylococcus Aureus, as well as gram-negative bacterial strain
Escherichia Coli[2].
Polygalacturonic acid (external application
14 d) enhances a quick healing of wound infection in albino rats[2].
| | | |
| | | | | |
[1]. Lin CY, et al. Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. J Biomater Appl. 2016 May
30(10):1589-600. [Content Brief]
[2]. El-Aassar MR, et al. Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies. Carbohydr Polym. 2020 Jun 15
238:116175. [Content Brief]