Anifrolumab MedChemExpress (MCE)

Product Name	Anifrolumab
Synonyms	Anifrolumab
CAS	1326232-46-5
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Anifrolumab Anifrolumab MedChemExpress (MCE) HY-P99168 1326232-46-5 99.48% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research. Anifrolumab (67.7 nM Descriptions Anifrolumab Anifrolumab MedChemExpress (MCE) HY-P99168 1326232-46-5 99.48% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research. Anifrolumab (67.7 nM 20 min) induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation[2]. Anifrolumab (1 and 10 μg/mL 6 or 7 d) suppresses differentiation of B cells into plasma cells[2]. Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively[2]. Anifrolumab (67.7 nM) dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[2]. Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Furie R, et al. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Feb 69(2):376-386. [Content Brief] [2]. Riggs JM, et al. Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus. Lupus Sci Med. 2018 Apr 5 5(1):e000261. [Content Brief]
Last Update	2025-04-01 14:45:47

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