Cixutumumab MedChemExpress (MCE)

Product Name	Cixutumumab
Synonyms	Cixutumumab
CAS	947687-12-9
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Cixutumumab Cixutumumab MedChemExpress (MCE) HY-P99189 947687-12-9 IMC-A12 Descriptions Cixutumumab Cixutumumab MedChemExpress (MCE) HY-P99189 947687-12-9 IMC-A12 NSC742460 99.63% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer. Cixutumumab (IMC-A12) (0.01-100 nM 96 h) exhibits at least 50% growth inhibition in CHLA-9, TC-71and Rh41 cells[1]. Cixutumumab (IMC-A12) (1 mg/rat i.p. twice weekly for 6 weeks) shows broad-spectrum antitumor activity, inhibits tumor growth of the PPTP’s in vivo solid tumor panels[1]. IGF-1R[1]. In Vitro Cixutumumab (IMC-A12) (0.01-100 nM 96 h) exhibits at least 50% growth inhibition in CHLA-9, TC-71and Rh41 cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cixutumumab Related Antibodies Cell Viability Assay[1] Cell Line: CHLA-9, TC-71, Rh41 cells Human Human IgG1 lambda1 Human IgG1 lambda1, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Houghton PJ, et al. Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer. 2010 Jul 1 54(7):921-6. [Content Brief]
Last Update	2025-04-01 14:45:47

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