CTX-471 MedChemExpress (MCE)

Product Name	CTX-471
Synonyms	CTX-471
CAS	2377152-49-1
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	CTX-471 CTX-471 MedChemExpress (MCE) HY-P99178 2377152-49-1 99.42% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer. CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively[1]. CTX-471 binds to a unique epitope on CD137[1]. CTX-471 (0.1-100 nM Descriptions CTX-471 CTX-471 MedChemExpress (MCE) HY-P99178 2377152-49-1 99.42% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer. CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively[1]. CTX-471 binds to a unique epitope on CD137[1]. CTX-471 (0.1-100 nM 1, 10 μg/mL 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro[1]. CTX-471 (i.p. 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors. CTX-471 (i.v. 10-80 mg/kg on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses. Kd for CD137: 50 nM (human) 61 nM (cynomolgus macaque) 748 nM (mouse)[1] In Vitro CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with Kd values of 50 nM, 61 nM and 748 nM, respectively[1]. CTX-471 binds to a unique epitope on CD137[1]. CTX-471 (0.1-100 nM 1, 10 μg/mL 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CTX-471 Related Antibodies Human \| \| \| \| \| \| \| \| \| \| [1]. Ugur Eskiocak, et al. Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity. JCI Insight. 2020 Mar 12 5(5):e133647. [Content Brief]
Last Update	2025-04-01 14:45:47

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