Evinacumab MedChemExpress (MCE)

Product Name	Evinacumab
Synonyms	Evinacumab;Anti-Human ANGPTL3(Evinacumab)
CAS	1446419-85-7
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	Evinacumab Evinacumab MedChemExpress (MCE) HY-P99194 1446419-85-7 REGN1500 98.98% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia. Evinacumab (REGN1500) (10 mg/kg Descriptions Evinacumab Evinacumab MedChemExpress (MCE) HY-P99194 1446419-85-7 REGN1500 98.98% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia. Evinacumab (REGN1500) (10 mg/kg s.c. single) lowers serum TGs in normolipidemic C57Bl/6 mice and increases postheparin plasma LPL activity[1]. Evinacumab (25 mg/kg s.c. once weekly for 8 weeks) lowers serum TG and cholesterol levels in dyslipidemic C57Bl/6 mice[1]. Evinacumab (10 mg/kg s.c. single) lowers serum HDL-C by an EL-dependent mechanism in Lipg-/- mice[1]. ANGPTL3[1]. In Vivo Evinacumab (REGN1500) (10 mg/kg s.c. single) lowers serum TGs in normolipidemic C57Bl/6 mice and increases postheparin plasma LPL activity[1]. Evinacumab (25 mg/kg s.c. once weekly for 8 weeks) lowers serum TG and cholesterol levels in dyslipidemic C57Bl/6 mice[1]. Evinacumab (10 mg/kg s.c. single) lowers serum HDL-C by an EL-dependent mechanism in Lipg-/- mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57Bl/6 mice (8-week-old)[1]. Human Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Gusarova V, et al. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. J Lipid Res. 2015 Jul 56(7):1308-17. [Content Brief]
Last Update	2025-04-01 14:45:47

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