KWAR 23 MedChemExpress (MCE)

Product Name	KWAR23 (anti-SIRPg)
Synonyms	KWAR23 (anti-SIRPg)
CAS	2243227-60-1
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	KWAR 23 KWAR 23 MedChemExpress (MCE) HY-P99175 2243227-60-1 99.80% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research. KWAR 23 (0-1 μM Descriptions KWAR 23 KWAR 23 MedChemExpress (MCE) HY-P99175 2243227-60-1 99.80% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. KWAR23 is an anti-human SIRPα antibody. KWAR23 binds human SIRPα with high affinity and disrupts its binding to CD47. KWAR23 shows antitumor activity in combination with tumor-opsonizing antibodies and can be used in cancer immunotherapy research. KWAR 23 (0-1 μM 4 h) shows antitumor activity of human neutrophil and macrophage[1]. KWAR 23 induces human macrophage-dependent phagocytosis in human tumor-derived cell lines[1]. KWAR23 (intraperitoneal injection 10 mg/kg every other day 21 d) exhibits effective antitumor activity in a human SIRPA knockin mouse model[1]. KWAR23 enhances neutrophil and macrophage antitumor activity in SRG Mice[1]. Human Human IgG4 kappa Human IgG4 (S228P) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Ring NG, et al. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proc Natl Acad Sci U S A. 2017 Dec 5 114(49):E10578-E10585. [Content Brief]
Last Update	2025-04-01 14:45:47

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