Rolinsatamab MedChemExpress (MCE)

Product Name	Rolinsatamab
Synonyms	Rolinsatamab
CAS	2095467-30-2
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	Rolinsatamab Rolinsatamab MedChemExpress (MCE) HY-P99238 2095467-30-2 97.16% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C). Chimeric Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Anderson MG, et al. ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. BMC Cancer. 2021 Jun 9 Descriptions Rolinsatamab Rolinsatamab MedChemExpress (MCE) HY-P99238 2095467-30-2 97.16% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C). Chimeric Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Anderson MG, et al. ABBV-176, a PRLR antibody drug conjugate with a potent DNA-damaging PBD cytotoxin and enhanced activity with PARP inhibition. BMC Cancer. 2021 Jun 9 21(1):681. [Content Brief]
Last Update	2025-04-01 14:45:47

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