Ponsegromab MedChemExpress (MCE)

Product Name	Ponsegromab
Synonyms	Ponsegromab
CAS	2368950-15-4
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Ponsegromab Ponsegromab MedChemExpress (MCE) HY-P99241 2368950-15-4 PF 06946860 99.41% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers. GDF15[1] Clinical Trial Humanized Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. E.J. Roeland, et al. 1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer. VOLUME 32, SUPPLEMENT 5, S1185, SEPTEMBER 01, 2021. Annals of oncology. [2]. Groarke JD, et al. Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med. 2024 Dec 19 Descriptions Ponsegromab Ponsegromab MedChemExpress (MCE) HY-P99241 2368950-15-4 PF 06946860 99.41% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 monoclonal antibody with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers. GDF15[1] Clinical Trial Humanized Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. E.J. Roeland, et al. 1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer. VOLUME 32, SUPPLEMENT 5, S1185, SEPTEMBER 01, 2021. Annals of oncology. [2]. Groarke JD, et al. Ponsegromab for the Treatment of Cancer Cachexia. N Engl J Med. 2024 Dec 19 391(24):2291-2303. [Content Brief]
Last Update	2025-04-01 14:45:47

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