Canakinumab MedChemExpress (MCE)

Product Name	Canakinumab
Synonyms	Canakinumab;Anti-Human IL-1B(Canakinumab)
CAS	914613-48-2
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg
Price	Email to quote
Descriptions	Canakinumab Canakinumab MedChemExpress (MCE) HY-108810 914613-48-2 Ilaris Descriptions Canakinumab Canakinumab MedChemExpress (MCE) HY-108810 914613-48-2 Ilaris ACZ 885 99.64% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin. Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2]. IC50: 43.6 pM (human IL-1β), 40.8 pM (marmoset IL-1β)[2] In Vitro Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β[2]. Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Canakinumab Related Antibodies Human Human IgG1(K214R) kappa Human IgG1 (K214R) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. [Content Brief] [2]. Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015 7(6):1151-60. [Content Brief]
Last Update	2025-04-01 14:45:47

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