Lucatumumab MedChemExpress (MCE)

Product Name	Lucatumumab
Synonyms	Lucatumumab
CAS	903512-50-5
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Lucatumumab Lucatumumab MedChemExpress (MCE) HY-P99167 903512-50-5 HCD122 98.18% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research. Lucatumumab (0.001-10 μg/mL Descriptions Lucatumumab Lucatumumab MedChemExpress (MCE) HY-P99167 903512-50-5 HCD122 98.18% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research. Lucatumumab (0.001-10 μg/mL 4 h 37 ℃) inhibit B-cell chronic lymphocytic leukemia (B-CLL) growth by ADCC-mediated cell lysis, with the average maximal lysis of B-CLL cells of 49%[1]. Lucatumumab (0.1-10 μg/mL 3 d) inhibits CD40L-induced signaling and viability of B-CLL cells[1]. Lucatumumab (10 μg/mL 24 h) inhibits cytokine secretion by B-CLL cells[1]. CD40 Human Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Luqman M, et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood. 2008 Aug 1 112(3):711-20. [Content Brief] [2]. Drgona L, et al. ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid or myeloid cells surface antigens [II]: CD22, CD30, CD33, CD38, CD40, SLAMF-7 and CCR4). Clin Microbiol Infect. 2018 Jun 24 Suppl 2:S83-S94. [Content Brief]
Last Update	2025-04-01 14:45:47

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