Gevokizumab MedChemExpress (MCE)

Product Name	IMMunoglobulin G2
Synonyms	Gevokizumab;IMMunoglobulin G2
CAS	1129435-60-4
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Gevokizumab Gevokizumab MedChemExpress (MCE) HY-P99171 1129435-60-4 98.12% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II). Gevokizumab (5 nM Descriptions Gevokizumab Gevokizumab MedChemExpress (MCE) HY-P99171 1129435-60-4 98.12% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II). Gevokizumab (5 nM 16 h) shows inhibitory effects of IL-1β-mediated NF-kB activation caused by the soluble receptors, sIL-1RI and sIL-1RII in HeLa cells[1]. Gevokizumab (1.85, 5.55, 16.66, and 50 nM) is a selective negative allosteric modulator which reduces the binding affinity of sIL-1RI to IL-1β[1]. Gevokizumab (1 mg/kg i.v. once daily for 3 d) improves endothelial regrowth and reduces neointima formation in rats following carotid denudation[2]. Humanized Human IgG2 kappa Human IgG2 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Issafras H, et al. Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1β antibody with differential receptor-modulating properties. J Pharmacol Exp Ther. 2014 Jan 348(1):202-15. [Content Brief] [2]. Roubille F, et al. The interleukin-1β modulator gevokizumab reduces neointimal proliferation and improves reendothelialization in a rat carotid denudation model. Atherosclerosis. 2014 Oct 236(2):277-85. [Content Brief]
Last Update	2025-04-01 14:45:47

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