Naxitamab MedChemExpress (MCE)

Product Name	Naxitamab
Synonyms	Naxitamab
CAS	1879925-92-4
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Naxitamab Naxitamab MedChemExpress (MCE) HY-P99206 1879925-92-4 Naxitamab-gqgk Descriptions Naxitamab Naxitamab MedChemExpress (MCE) HY-P99206 1879925-92-4 Naxitamab-gqgk Humanized 3F8 Hu3F8 98.13% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Naxitamab (Hu3F8) is a humanized monoclonal antibody targeting the disialoganglioside GD2. Naxitamab can be used in research of neuroblastoma, osteosarcoma and other GD2-positive cancers. Naxitamab (Hu3F8 72 h) has cytotoxicity against neuroblastoma cell line LAN-1 with an EC50 value of 5.1 μg/mL[1]. Naxitamab (0.1-1 μg/mL 4 h peripheral blood mononuclear cells (PBMC) and polymorphonuclear leukocytes (PMN)) has antibody-dependent cell-mediated cytotoxic effects (ADCC)[1]. Naxitamab (Hu3F8 100 mg/kg i.v. twice a week, for 4 weeks athymic nude mice with LAN-1 xenografts) inhibits tumor growth in neuroblastoma xenografts[1]. Chimeric Human IgG1 kappa Human IgG1 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Cheung NK, et, al. Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo. Oncoimmunology. 2012 Jul 1 1(4):477-486. [Content Brief] [2]. Markham A. Naxitamab: First Approval. Drugs. 2021 Feb 81(2):291-296. [Content Brief]
Last Update	2025-04-01 14:45:47

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