Robatumumab MedChemExpress (MCE)

Product Name	Robatumumab
Synonyms	Robatumumab
CAS	934235-44-6
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Robatumumab Robatumumab MedChemExpress (MCE) HY-P99218 934235-44-6 Sch 717454 Descriptions Robatumumab Robatumumab MedChemExpress (MCE) HY-P99218 934235-44-6 Sch 717454 19D12 99.90% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Robatumumab (Sch 717454) is an anti-human IGF-1R (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research. Robatumumab (0.02-80 nM 0.5 or 4 h) downregulates IGF-IR and inhibits both basal and IGF-I-induced phosphorylation of IGF-IR and IRS-1 in SK-N-FI cells[2]. Robatumumab (intravenous injection 0.04 or 0.1 mg/mouse twice weekly 18 d) inhibits the SK-N-FI tumor growth in xenograft model[2]. Robatumumab (intravenous injection 0.02-0.5 mg/mouse twice weekly 35 d) inhibits the osteosarcoma growth in xenograft model[2]. Robatumumab (intravenous injection 0.1 or 0.5 mg/mouse twice weekly 14 d) inhibits the SJCRH30 and RD rhabdomyosarcoma cell growth in xenograft model[2]. Robatumumab (intravenous injection 0.1 or 0.5 mg/mouse twice weekly 2 w) blocks effectively pediatric tumor cell proliferation in vivo[2]. Robatumumab (intravenous injection 0.5 mg/mouse once day 11 post-inoculation) modulates the blood vessel formation via its antiangiogenesis effect[2]. Human Human IgG1(E356D/M358L) kappa Human IgG1(E356D/M358L) kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Anderson PM, et al. A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma. Pediatr Blood Cancer. 2016 Oct 63(10):1761-70. [Content Brief] [2]. Wang Y, et al. A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts. Mol Cancer Ther. 2010 Feb 9(2):410-8. [Content Brief]
Last Update	2025-04-01 14:45:47

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