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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameMirvetuximab
SynonymsMirvetuximab
CAS1453084-36-0
EINECS
Chemical Formula
Molecular Weight
inchi
Package1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
PriceEmail to quote
DescriptionsMirvetuximab

Mirvetuximab

MedChemExpress (MCE)

HY-P99225

1453084-36-0

M9346A

99.88%

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping with dry ice.

Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research.

Mirvetuximab (0.17 pM-81 nM, 2 h) bounds three antibodies bound with high affinity, with EC50 values in the double-digit picomolar range (14.3, 16.5, and 21.1 pM for binding to clones 4E12-G5, 4E12-B9, and 5D12-C11, respectively)[2]. Mirvetuximab (1 pM-100 nM) shows dose-dependent binding to folate receptor in the absence of competing anti-idiotype antibodies[2]. M9346A (1 pM-100 nM) associates with H2110 cells with an EC50 of around 650 pM by specific binding of M9346A to surface folate receptor antigen[2].

Chimeric

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

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[1]. Moore KN, et al. Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study. J Clin Oncol. 2017 Apr 1

Descriptions

Mirvetuximab

Mirvetuximab

MedChemExpress (MCE)

HY-P99225

1453084-36-0

M9346A

99.88%

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping with dry ice.

Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research.

Mirvetuximab (0.17 pM-81 nM, 2 h) bounds three antibodies bound with high affinity, with EC50 values in the double-digit picomolar range (14.3, 16.5, and 21.1 pM for binding to clones 4E12-G5, 4E12-B9, and 5D12-C11, respectively)[2]. Mirvetuximab (1 pM-100 nM) shows dose-dependent binding to folate receptor in the absence of competing anti-idiotype antibodies[2]. M9346A (1 pM-100 nM) associates with H2110 cells with an EC50 of around 650 pM by specific binding of M9346A to surface folate receptor antigen[2].

Chimeric

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

| | | |

| | | | | |



[1]. Moore KN, et al. Safety and Activity of Mirvetuximab Soravtansine (IMGN853), a Folate Receptor Alpha-Targeting Antibody-Drug Conjugate, in Platinum-Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer: A Phase I Expansion Study. J Clin Oncol. 2017 Apr 1
35(10):1112-1118. [Content Brief]

[2]. Loebrich S, et al. Development and Characterization of a Neutralizing Anti-idiotype Antibody Against Mirvetuximab for Analysis of Clinical Samples. AAPS J. 2017 Jul
19(4):1223-1234. [Content Brief]

[3]. Ab O, et al. IMGN853, a Folate Receptor-α (FRα)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FRα-Expressing Tumors. Mol Cancer Ther. 2015 Jul
14(7):1605-13. [Content Brief]

Last Update2025-04-01 14:45:47
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