Figitumumab MedChemExpress (MCE)

Product Name	Figitumumab
Synonyms	Figitumumab
CAS	943453-46-1
EINECS
Chemical Formula
Molecular Weight
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Figitumumab Figitumumab MedChemExpress (MCE) HY-P99197 943453-46-1 CP-751871 96.89% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM. Figitumumab (CP-751871) (152 pM-10 μM Descriptions Figitumumab Figitumumab MedChemExpress (MCE) HY-P99197 943453-46-1 CP-751871 96.89% Please store the product under the recommended conditions in the Certificate of Analysis. Shipping with dry ice. Figitumumab (CP-751871) is a potent and fully human monoclonal anti–insulin-like growth factor 1 receptor (IGF1R) antibody. Figitumumab prevents IGF1 from binding to IGF1R with an IC50 of 1.8 nM. Figitumumab (CP-751871) (152 pM-10 μM 3 days) inhibits cancer cell proliferation[1]. Figitumumab (1 μg/mL 1 min or 24 h) induces the down-regulation of IGF-1R[2]. Figitumumab inhibits IGF1-induced autophosphorylation of IGF1R with an IC50 of 0.42 nM, and indirectly inhibits AKT activation[2]. Figitumumab recognizes the IGF-1R/IR heterodimer complex[2]. Figitumumab (CP-751871) (31-125 μg/mouse i.p. once) induces the down-regulation of tumor associated IGF-1R in mice[2]. Figitumumab (62.5-500 μg/mouse i.p. once) inhibits the growth of s.c. xenografts derived from colon (Colo-205), breast (MCF7), and lung (H460) cancer cell lines in mice[2]. IC50: 1.8 nM (IGF1R)[1] In Vitro Figitumumab (CP-751871) (152 pM-10 μM 3 days) inhibits cancer cell proliferation[1]. Figitumumab (1 μg/mL 1 min or 24 h) induces the down-regulation of IGF-1R[2]. Figitumumab inhibits IGF1-induced autophosphorylation of IGF1R with an IC50 of 0.42 nM, and indirectly inhibits AKT activation[2]. Figitumumab recognizes the IGF-1R/IR heterodimer complex[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Figitumumab Related Antibodies Cell Proliferation Assay[1] Cell Line: Breast, colon, lung small cell, and non–small cell cancer lines Human Human IgG2 kappa Human IgG2 kappa, Isotype Control \| \| \| \| \| \| \| \| \| \| [1]. Pavlicek A, et al. Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871). Mol Cancer Ther. 2013 Dec 12(12):2929-39. [Content Brief] [2]. Cohen BD, et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res. 2005 Mar 1 11(5):2063-73. [Content Brief]
Last Update	2025-04-01 14:45:47

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