Cyclo(Arg-Gly-Asp-D-Phe-Cys) MedChemExpress (MCE)

Product Name	Cyclo(-Arg-Gly-Asp-D-Phe-Cys)
Synonyms	RGDFC RGDfC C(RGDFC) CYCLO(ARG-GLY-ASP-D-PHE-CYS) Cyclo(-Arg-Gly-Asp-D-Phe-Cys) CYCLO (ARG-GLY-ASP-D-PHE-CYS) c(RGDfC),cyclo(Arg-Gly-Asp-d-Phe-Cys) Synonyms RGDFC RGDfC C(RGDFC) CYCLO(ARG-GLY-ASP-D-PHE-CYS) Cyclo(-Arg-Gly-Asp-D-Phe-Cys) CYCLO (ARG-GLY-ASP-D-PHE-CYS) c(RGDfC),cyclo(Arg-Gly-Asp-d-Phe-Cys) Cyclo(-Arg-Gly-Asp-D-Phe-Cys) Acetate salt Cyclo(-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide Cyclo(-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide, c(RGDfC)
CAS	862772-11-0
EINECS
Chemical Formula	C24H34N8O7S
Molecular Weight	578.65
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(Arg-Gly-Asp-D-Phe-Cys) MedChemExpress (MCE) HY-P2300 862772-11-0 Cyclo(RGDfC) 99.70% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions Cyclo(Arg-Gly-Asp-D-Phe-Cys) Cyclo(Arg-Gly-Asp-D-Phe-Cys) MedChemExpress (MCE) HY-P2300 862772-11-0 Cyclo(RGDfC) 99.70% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) Room temperature in continental US may vary elsewhere. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs[1]. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs[1]. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM)-treated mESC leads to the formation of aggregates and detachment from the surface[1]. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM, 24 h)-treated mESCs in the presence/absence of Leukemia inhibitory factor (LIF) (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mESC tumor formation in vivo is dependent on integrin interaction[1]. αvβ3 \| \| \| \| \| \| \| \| \| \| [1]. Hazenbiller O, et al. Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide. BMC Cell Biol. 2017 Nov 14 18(1):32. [Content Brief]
Last Update	2025-04-01 14:45:47

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